本遊戲中所謂的「結局」即有關玩家的遊玩情況與表現，它會在玩家達到某個遊戲結束條件則會觸發，如毀滅世界或被滅絕（被解藥根治/所有宿主死亡）。
以下為遊戲中的結局文字一覽。
- 註：瘟疫名稱以(?)代替。彩色的標題代表對應病原體勝利/失敗時的顏色（以原版為準）。
勝利
- (?) has successfully eliminated all life on Earth.
- (?)已經成功地滅絕了地球上所有的生物。
失敗
- (?) has been eradicated.
- (?)已被根除。（如果玩家的病原體被解藥根治）
- (?) has killed all its hosts. Some healthy people survived!
- （待補充）（如果玩家的病原體殺死了所有目前被感染的宿主而有一部分健康人口殘留）
勝利 (進化超然存在下)
- (?) has enslaved all life on Earth.
- (?)奴役了地球上所有的生物。（只在原版出現）
- The whole world worships (?) as their god an master. Efforts to cure the plague have ceased and humanity is entering a dark new future as a slave species.
- (?)（只在《瘟疫公司：物競天擇》中出現，但是內容是兩版本的超然存在勝利彈窗內容）
勝利（在殭屍模式下）
- (?) and its zombies have consumed Humanity! There is nothing left.
- 感染(?)的殭屍將人類捕殺殆盡！世界已重陷死寂。
失敗 (當所有殭屍死亡)
- Humans fought the zombies and won! (?) is no longer a threat.
勝利（進化猿猴神經世代下）
- (?) has destroyed all of humanity. The planet belongs to the apes now!
- (?) has created The Planet of the Apes.
失敗
- (?) has killed all its hosts! Apes and humans face an uncertain future.
- （殺滅所有宿主）
- (?) has been eradicated. Apes and humans face an uncertain future.
- （被解藥根除）
勝利
- (?) has corrupted humanity. Vampires rule the world now!（進化暗影奴隸）
- (?)摧毀人類文明。血族勢力重建紅魔之鄉！
- (?) has corrupted humanity. The world falls into shadow.
失敗
- Humanity defeats the Vampires.
- （所有的吸血鬼全部死亡）
- The Vampires and (?) have been eradicated. ( By eradicated by cure )
- （病原體被解藥根治）