Unlock Annihilate gene is a unique ability exclusive to Bio-Weapon.


  • Provides a massive boost to all three stats, but for the most part, it increases lethality to maximum.
  • It turns the Bio-Weapon into an extremely deadly disease which can wipe Earth clean in a matter of weeks.
  • In order for the ability to show up, all other special abilities of the Bio-Weapon must be purchased beforehand.
  • This is the most lethal trait in Plague Inc, and is what makes the Bio-Weapon so unique.
  • It is worth mentioning that this ability needs to be used properly to win. Shouldn’t be evolved too early, it could end up killing all infected while leaving some healthy people, so it should be used carefully.
  • It is best to evolve it when every country is well-infected, giving yourself time to completely infect all countries while rapidly killing off everyone.
  • Interestingly, it is also considered a Nucleic Acid Neutralisation and as such resets all existing lethality before rapidly going into effect over time. Whether this is intended is unknown.
  • Because this is an extremely lethal ability, you should not use this until everyone is infected.
  • This trait surprisingly has the same severity as Transcendence, which is also 40.
Community content is available under CC-BY-SA unless otherwise noted.