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Ultimate Christmas is a symptom combo exclusive to the Santa's Little Helper scenario. When this combo is active, Santa and Rudolph will come out of retirement and pose with children for pictures, making them very happy. It increases infectivity and happiness.

Symptom Combos
Standard Plagues Red RainOopsProfuse BleedingProjectile VomitingPublic DefecationRed RainSwine Flu
Simian Flu AssassinBlind GeniusDiscovery ChannelFly MagnetRed Ape RedemptionRude AwakeningZombie Panic
Necroa Virus Bath TimeBlood in the AirBoomerCranial DispersionRunnerSpitterTankWalking ContradictionWalking Dead
Shadow Plague Carpe JugulumVampire Bat
Cure Mode Report thy neighbourRules are for losersWe're here to helpHappy FrogsWeapon XIn it togetherHumans weren't meant to fly Shut down everything
Santa's Little Helper On The Naughty ListUltimate Christmas
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