Stn Total Organ Failure
Total Organ Failure
Total Organ Failure
A patient suffering from total organ failure.


Catastrophic cell death of multiple tissue types causes body-wide organ failure and rapid death

DNA cost



Catastrophic (20)


Catastrophic (25)



Required Symptoms

Immune Suppression, Coma, or Pulmonary Fibrosis

Total Organ Failure is a Tier 4 symptom. It causes catastrophic cell death of multiple tissue types, which causes body-wide organ failure and rapid death. It increases severity by 20%, and lethality by 25%. This is the only symptom which does not increase cure requirement.


Total Organ Failure is arguably one of the most lethal symptoms in the game and once evolved, it kills rapidly. Even wealthy countries will go down if enough people are infected. However, this extreme lethality increase is a double-edged sword. This symptom can backfire if not handled correctly.

Total Organ Failure should not be evolved before most of the world's population is already infected (for example: 75% of the population, including a fair chunk of Greenland and other hard-to-reach countries). It is commonly used to kill off the world's population rapidly, and is highly recommended to be used at the end of the game to end the game quickly. However, evolving it too early can often result in a game over, as all infected will likely die off before they are able to infect all healthy people.

Interestingly, this symptom loses much of its lethality in the scenario Artificial Organs, due to the organs are no longer organic and thus can barely have any effect.

Trivia Edit

This is as lethal as Cytokine storm and Vampiric Awakening, but not as lethal as Simian Flu symptom Total Brain Death or the Bioweapon ability Unlock Annihilate gene.

You can actually evolve Total Organ Failure without Immune Suppression or Pulmonary Fibrosis, such as with this path: Cysts -> Hypersensitivity -> Paralysis -> Coma -> Total Organ Failure, however, this path is more expensive, as there are a total of five symptoms in the path, and isn’t recommended unless getting Coma was also in the player’s interest.

Symptoms in Plague Inc. and Plague Inc: Evolved.
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AbscessesAcidic RefluxAcute EncephalitisAdorationAdrenal Surge (Symptom)Adrenergic ConstrictionAffectionAggressionAkinetopsiaAnabolic BoostAnabolic Boost (Shadow Plague)AnaemiaAnaemia (Shadow Plague)Anaerobic ResuscitationAneurysmAnxiolytic InfusionAphasiaAppreciationApraxiaAutophagiaAutophagia (Shadow Plague)AutothysisBlindnessBlood Sacrifice 1Blood Sacrifice 2Blurred VisionBone DysplasiaBrain HaemorrhageBuboesCannibalismCarnivorous DenticulationCathemeral ShiftCerebral TendrilsCognitive ScramblingComaConfusionContentednessCorneal UlcerationCoughingCranial ElephantitisCranial Elephantitis (Necroa Virus)CystsCytokine StormCytopathic ReanimationDark PustlesDeliriumDermal CalcificationDermal Calcification (Shadow Plague)DespairDevotionDiarrhoeaDigital AngelDigital ElfDigital HeraldDroolingDrowsinessDysenteryDysphagiaDyspneaEdentulismEncephalitisEnhanced Motor ControlEnhanced Sensory IntegrationEpistaxisExcitementFatigueFestive TendrilsFeverFriendshipFrontal MeshGastric UlcerationGastroenteritisGluttonyHaemophiliaHaemoptysisHaemorrhagic Shock (Shadow Plague)HallucinationsHarmonyHeadacheHemorrhagic ShockHepatic FailureHydrocephalusHyper SalivationHyper sensitivityHyperdontiaHyperosmiaHypocoagulabilityHypotensionImmaturityImmune SuppressionIndulgenceInflammationInsanityInsomniaInternal HaemorrhagingInternal Haemorrhaging (Shadow Plague)IntoxicationJaundiceJealousyJoint PainJoyJugular BiteLatent AdaptationLaughterLoveLumbrical HypertrophyMalignant AscitesMalignant PigmentationMandibular StrainManiaMasticatory TensionMasticatory Tension (Shadow Plague)Memory LossMeningitisMuscular HypotrophyMyocarditisNaja MortisNauseaNeanderthal RegressionNecrosisNeural BreachNeuro-enhancement 1Neuro-enhancement 2Neuro-enhancement 3Nuchal rigidityObsessionOccipital MeshOsteomyelitisPallorParalysisParanoiaPartyingPeptide SurgePerceptive JoltPerceptive ShiftPharyngitisPheromone secretionPhotophobiaPhotophobia (Shadow Plague)PneumoniaPolyphagiaPsychosisPulmonary EmbolismPulmonary FibrosisPulmonary HaemorrhagePulmonary HypertensionPulmonary OedemaPurpuraPustulesRashRespiratory FailureSanta's Little Neurax WormSchizophreniaSeizuresShadow BlessingShadow SlavesSkin LesionsSlothSneezingSteroidal BoostSubconjunctival BleedSubconjunctival HaemorrhageSuicideSweatingSystemic InfectionTachycardiaTemporal Lobe ManipulationTotal Brain DeathTotal Organ FailureTranscendenceTumoursVampiric AwakeningVampiric HungerVomitingWeeping Sores

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