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Symptom Combos are special combinations of Symptoms (and in some cases Transmission traits or Abilities) that can affect the plague's Core stats or climate resistances, as well as trigger special events which can slow or speed up Cure progression, or draw attention to the disease. All combos have an achievement associated with them.

Note that it seems to take a while for symptom combos to appear and take effect. Please also note that the list may not be complete. Please feel free to add to the list.

Combos[]

To achieve a combo, one must evolve two or more different symptoms. They range from two tier 1 symptoms to eight symptoms and two infections, so using them is a viable strategy for new players and advanced players alike. Also be aware that once a combo has been triggered, it is not reversible and remains in effect even if you devolve the traits that caused it to trigger.

Standard Plagues[]

Name Effects Symptoms
Projectile Vomiting Increases infectivity

Vomiting

Coughing

Walking Dead Decreases Cure research rate

Insomnia

Anaemia

Profuse Bleeding Slightly increases lethality, greatly increases infectivity

Haemophilia

Skin Lesions

Oops

Lowers productivity but draws attention to the plague.

Diarrhoea

Sneezing

Public Defecation Increases infectivity and draws attention to disease. Increases research speed.

Insanity

Diarrhoea

Swine Flu Slight increase in work needed for a Cure. 10% increase in budget required for cure.

Coughing

Diarrhoea

Pneumonia

Vomiting

Livestock I

Livestock II

Insomnia


Necroa Virus[]

Name Effects Symptoms

Vampire Bat

Increases Severity, Infectivity, and Lethality.

Vampiric Hunger

Bat 1

Bat 2

Blood in the Air

Increases Severity

Cathemeral Shift

Delirium

Hyperosmia

Tank Slight Severity boost

Anabolic Boost

Bone Dysplasia

Spitter Slight Severity boost

Naja Mortis

Enhanced Sensory Integration

Boomer Slight Severity boost

Autothysis

Liquefactive Necrosis

Cranial Dispersion

Severity Boost

Cranial Elephantitis

Air 3

Walking Contradiction Slight Severity decline Photophobia, Cathemeral Shift
Runner Slight Severity boost

Enhanced Motor Control

Engorged Quadriceps

Bath Time Infectivity Boost

Autophagia

Cannibalism

Polyphagia


Simian Flu[]

Name Effects Symptoms
Assassin Increases Ape combat abilities

Ape Rampage

Primal Awareness

Blind Genius Increases Cure Production

Blindness

Neuro-enhancement 3

Discovery Channel Increases Ape to Ape transmission

Primal Hunt

Social Cohesion

Fly Magnet

Increases cross-species transmission

Hominidae Bridge

Excrement

Diarrhoea

Red Ape Redemption Increases Ape combat abilities

Horseback Riding

Weapon Creation

Rude Awakening Increases Ape to Ape transmission

Scouts

Excrement

Zombie Panic Slows Research Speed

Subconjunctival Haemorrhage

Total Brain Death

Bat 2

Blood 2

Shadow Plague[]

Name Effects Symptoms
Bat Cave Bat 3

Lair Healing 2

Plague Dogs Increases Infectivity Dog 2

Weeping Sores

Essential Vitamins Increases Infectivity

Blood 2

Hypocoagulability

Autophagia

Diamond Skin Increases Infectivity and Severity Anaemia

Pallor

Photophobia

Dermal Calcification

Welcome to Hellmouth Increases Deaths/Second for Blood Rages Demonic Fury

Shadow Portals

Carpe Jugulum Steroidal Boost

Anabolic Boost

Masticatory Tension

Blood Trumps All

Malignant Pigmentation

Shadow Slaves

Cranial Elephantitis

Evil Is A Point Of View Decreases Strength of Templars and of Government Actions

Pallor

Pheromone secretion

Hypersensitivity

Uphill Ice Skating Increases Deaths/Second for Blood Rages in Cold climates Extreme Bioaerosol

Shadow Blades

Cold Tolerance

Dentist's Dream

Hyperdontia

Masticatory Tension

Blood 2

Silent but Deadly Increases Severity

Corrupted Air

Night Wraith

Dark Infiltration

Dark Knight Increases Deaths/Second for Blood Rages

Bat 2

Night Wraith

Travel Speed 2

Mr. Universe Increases Infectivity

Anabolic Boost

Muscular Hypotrophy

Cure Mode[]

In Cure Mode, combos are referred to as Initiative Combos, but function identically to Symptom Combos.

Name Effects Initiatives

Report thy neighbour

Decreases Non-Compliance

Mask Wearing

Public Awareness

Rules are for losers

Increases Infection

Mask Wearing

Censorship

We're here to help Increases Infection

Deploy Field Operatives

Infection Control and PPE Package 1 cannot be funded

Happy Frogs Increases Infection

Field Research

Fake News

Weapon X Increases Infection

Steroid Medication

Censorship

In it together

Decreases Non-Compliance

Global Research Treaty

Global Manufacturing Treaty

Humans weren't meant to fly Decreases Vaccine Manufacturing speed Close Air Access on all continents
Shut down everything Decreases Infection Force Lockdown on all continents


Scenarios[]

Santa's Little Helper[]

Name Effects Symptoms
On The Naughty List Decreases happiness Gluttony
Intoxication
Sloth
Ultimate Christmas Increases happiness and infectivity Digital Elf
Red-Nosed Guide
Red-Suited Pilot

Ultimate Board Games[]

Fake News[]

Symptom Combos
Standard Plagues Red RainOopsProfuse BleedingProjectile VomitingPublic DefecationRed RainSwine Flu
Simian Flu AssassinBlind GeniusDiscovery ChannelFly MagnetRed Ape RedemptionRude AwakeningZombie Panic
Necroa Virus Bath TimeBlood in the AirBoomerCranial DispersionRunnerSpitterTankWalking ContradictionWalking Dead
Shadow Plague Carpe JugulumVampire Bat
Cure Mode Report thy neighbourRules are for losersWe're here to helpHappy FrogsWeapon XIn it togetherHumans weren't meant to fly Shut down everything
Santa's Little Helper On The Naughty ListUltimate Christmas
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