Swine Flu

"Patient Zero is infected with a new mutated strain of the Influenza A (H1N1) virus. It is a reassortment of the 2009 strain with limited lethality - existing anti-virals are moderately effective against it. However, analysis of its genetic makeup has identified potential sequence similarities to the 1918 'Spanish Flu' strain that killed 5% of the world's population. Will history repeat itself?" - Plague Inc., Swine Flu introduction paragraph

The Swine Flu is a scenario.

TransmissionsEdit

Zoonosis TransmissionsEdit

These Transmissions are available right at the start of the game without evolving other traits.

Swine 1	Pathogen uses pigs as prime host for antigenic shift - exchanging genes with multiple strains of influenza. (Note: Already evolved at the start of the game.)
Swine 2	Pigs more susceptible to infection by pathogen crossing species barrier. Increases infectivity, particularly in rural areas.
Livestock 1	Livestock susceptible to infection. Increase infectivity, especially in rural regions and mutation.
Livestock 2	Wildlife susceptible to infection. Increase infectivity, especially in rural regions and mutation.
Bird 1	Birds becom susceptible to infection. Avian carriers increase infectivity, land transmission and mutation.
Bird 2	Avian brain tissue compromised causing birds to attack other species. Increases mutation, infectivity and land based transmission.
Extreme Zoonosis	Infection crosses multiple species barriers. Increases infectivity, especially in rural and urban areas, mutation chance and cross-country transmission.

Bioaerosol TransmissionsEdit

These Transmissions are available to right at the start of the game without evolving any other traits.

Air 1	Gives pathogen ability to travel on dust particles. Increases infectivity, especially in arid environments and plane transmission.
Air 2	Gives organism ability to survive suspended in air for a long time. Increases infectivity, especially in arid environments and plane transmission.
Water 1	Pathogen can survive outside the body in fresh, warm water. Increase infectivity, especially in humid environments and ship transmission.
Water 2	Pathogen able to survive in chemically treated water. Increase infectivity, especially in humid environments and ship transmission.
Extreme Bioaerosol	Pathogen bypasses air/water filters due to adaptive cellular shell. Increase infectivity, especially in humid & arid climates and plane/ship transmission.

Droplets TransmissionsEdit

These Transmissions are available to you right at the start of the game without using any DNA points.

Droplets 1	Pathogen suspended in expelled liquid particles from victim. Increase infectivity, especially on planes.
Droplets 2	Pathogen able to survive for longer in expelled droplets. Increase infectivity, especially on planes.
Blood 1	Gives organism ability to spread through blood-to-blood contact. Increases infectivity, especially in poor regions and mutation chance.
Blood 2	Infected bodily fluids able to pass through mucous membranes. Increases infectivity, especially in poor regions and mutation chance.

SymptomsEdit

H1N1 Flu SymptomsEdit

These are the Symptoms that are available to the player right at the start of the game without using any DNA points.

Tier 1
Nausea	Irritated stomach lining leads to discomfort. Slight chance of infection when kissing.
Coughing	Chance of infection by spreading pathogen into surroundings, especially in high density urban areas. (Note: Already evolved from the start of the game.)
Pharyngitis	Sore throat causes discomfort and increases likelihood that coughing will spread disease. (Note: Already evolved from the start of the game.)
Rash	The skin becomes blistered and painful, slightly increasing infectivity.
Insomnia	Inability to sleep makes people irritable and less productive.

Tier 2
Vomiting	The expulsion of infected material through projectile vomiting increases the risk of infection.
Pneumonia	Serious fluid build and discharge from the lungs. People in cold climates especially vulnerable. (Note: Already evolved from the start of the game.)
Sneezing	Fluid discharge through sneezing greatly increases infection rates. (Note: Already evolved from the start of the game.)
Inflammation	Inflammation obstructs bodily processes. Swelling can obstruct breathing and be fatal.
Paranoia	Irrational delusions and mental symptoms. Victims distrust of others makes them unlikely to seek treatment or cooperate with others.
Fatigue	Extreme tiredness makes people weaker and less productive.

Tier 3
Pulmonary Oedema	Potentially fatal heart abnormality causes breakdown of respiratory system, releasing pathogen into the air.
Hyper sensitivity	Increases likelihood of allergic reactions which can distract the immune system. Rich regions particularly vulnerable.
Headache	Strong headache behind the eyes causes discomfort and reduces ability to work. (Note: Already evolved from the start of the game.)

Tier 4
Diarrhoea	Pathogen active in digestive tract, causing infection through faeces and potentially lethal dehydration. Poor countries very vulnerable.
Pulmonary Fibrosis	Scarring of the lungs causes shortness of breath and extreme coughing. Can be fatal when combined with intense exercise.
Pulmonary Embolism	Blockage in the pulmonary artery prevents blood from reaching the lungs. Severe and potentially fatal.
Myocarditis	Infection inflames and damages heart muscles. Severe and potentially fatal.

Tier 5
Dysentery	A complete breakdown in the digestive system causes infected sewage, dehydration, starvation and death.
Systemic Infection	Pathogen affects multiple organs and tissue types, causing body-wide infections that spread fast and can be fatal.
Coma	Neuropathic effects in the brain stem causes loss of consciousness and sometimes death. Significantly harder to cure.
Immune Suppression	Pathogen attach to lymphocytes, suppressing immune system and allowing significantly greater freedom of mutation. Can be lethal.
Fever	Increase in temperature, contagiousness and severe dehydration, which can be fatal. (Note: Already evolved from the start of the game.)

1918 Spanish Flu SymptomsEdit

These Symptoms can only be taken by first taking the 'Historic Reassortment' ability, available at the start of the game.

Tier 1
Epistaxis	Haemorrhage of the nasal mucous membranes causes severe nosebleeds.

Tier 2
Haemoptysis	Coughing up blood from inflames bronchi increases infectivity and is fatal in extreme cases.
Haemorrhagic Shock	Severe loss of blood volume causes oxygen deprivation, loss of consciousness and death.

Tier 3
Pulmonary Haemorrhage	Severe bleeding through the lungs increases infectivity and can result in asphyxiation.

Tier 5
Total Organ Failure	Catastrophic cell death of multiple tissue types causes body-wide organ failure and rapid death.
Cytokine Storm	Positive feedback loops between cytokines and immune cells causes fatal immune reaction. Can offer insights into cure development.

AbilitiesEdit

Climate AbilitiesEdit

These abilities will affect the plague in different countries, climates and temperatures.

Cold Resistance 1	Pathogen evolves to withstand cold temperatures and climates.
Cold Resistance 2	Lower intracellular water volume prevents freezing. Increased effectiveness in cold climates
Heat Resistance 1	Pathogen evolves to withstand hot temperatures and climates
Heat Resistance 2	Pathogen avoids cellular breakdown in high temperatures. Increased effectiveness in hot climates.
Environmental Hardening	Pathogen develops hardened coating - becoming highly weather resistant and extremely comfortable in both hot and cold climates.

Cure/Drug Resistance AbilitiesEdit

These abilities will affect the plague's resistance against treatments and drugs. They will also slow down cure creation speed and increase more work required to create a cure.

Drug Resistance 1	Pathogen becomes resistant to class 1 and 2 antibiotics. Increase effectiveness in wealthy countries.
Drug Resistance 2	Pathogen develops resistance to class 3 and 4 antibiotics. Increase effectiveness in wealthy countries.
Genetic Hardening 1	Pathogen becomes harder to analyse in the lab. Decreases future research speed.
Genetic Hardening 2	The pathogen does not reproduce in lab conditions. Decreases future research speed.
Genetic ReShuffle 1	Pathogen DNA strands reassembled. More work needed to develop a cure.
Genetic ReShuffle 2	A new strain of the pathogen now exists, increasing the work needed to develop a cure.
Genetic ReShuffle 3	Multiple strains of the pathogen now exists, increasing the work needed to develop a cure.

Unique AbilitiesEdit

These are abilities exclusive to the plague, Swine Flu

Viral Instability 1	DNA becomes more unstable, increasing random mutations.
Viral Instability 2	DNA occasionally fractures, increasing random mutations.
Viral Instability 3	DNA becomes highly erratic and fragmented, increasing random mutations.
Bacterial Pneumonia	Pathogen damages pulmonary lining, allowing lethal secondary bacterial infections. Antibiotics will reduce impact.
Historic Reassortment	Gives ability to access the genetic sequence in the 1918 flu. Highly lethal strain.