The following are strategies for the Pirate Plague Scenario. Please feel free to add your own strategies, tips, and Q&A here:

Strategy 1

Recommended genes:

  1. Start in Saudi Arabia, Casual Difficulty, with the Neurax Worm.
  2. Evolve Eggs 1, Eggs 2, Concertina Locomotion, and Undulatory Locomotion.
  3. Evolve Trojan Planes 1, Water 1, and Air 1.
  4. Once Occipital Mesh mutates, send the Trojan Planes to the following areas, in this order:Caribbean,Iceland,Greenland,New Zealand,Madagascar,New Guinea, and Philippines. Indonesia will be infected by S.E. Asia as if the two share a land border.
  5. Evolve Genetic Swap, Mutative Regeneration 1, and Mutative Regeneration 2. Allow symptoms to mutate naturally. It'll make things easier in the future.
  6. Evolve Cold Resistance 1 and 2, and Drug Resistance 1. Due to the hot, arid climate of Saudi Arabia, Heat 1 may not be necessary, but can be evolved when desired.
  7. Wait until the majority of the world is infected, and evolve symptoms up to Transcendence. One option is to evolve the following symptoms: Adrenergic Constriction, Anxiolytic Infusion, Psychosis, Adoration, and Transcendence.
  8. Evolve Genetic Hardening 1 and Genetic ReShuffle 1 to stall cure effort.
  9. Send Trojan Planes to countries that haven't been completely infected.
  10. Watch as the world burns.

Strategy 2 (Works with all plague type, but Not Mega Brutal Mode)

Disclaimer:Do not Dare to Try this on mega brutal. You will result in a terrible failure because of the ‘Random Medical Check Up’.

Bacteria, Virus and Parasite

Genetic Code:

Metabolic Jump

Genetic Mimic




  1. Start in Saudi Arabia
  2. Use the first DNA to get Rash
  3. Get Sweating, Skin Lesions
  4. Go for Water 1 and 2, Bird 1 and insect 1.
  5. Get Coughing, Phenomena and Sneezing
  6. Once the plague gets into any Wealthy Country, Get Drug Resistance 1. Same, if the plague gets into RUSSIA, Get Cold resistance 1 and 2 immediately
  7. Get Rodent 1, Livestock 1 and blood 1.
  8. Get Drug resistance 2
  9. Despite of all the evolution, Your plague should be already detected. Get Genetic hardening 1
  10. Save your file if you can.
  11. Get insomnia, paranoia and Nasuea.
  12. Now the plague is in most countries. Get these symptoms in order: Necrosis, Immue Suppression, Total Organ Failure, Seziures, Insanity, Heammorage Shock, Dystinary and Coma.
  13. If any island country closes port before infection, Load file or just restart
  14. watch the world Die, and get all Genetic reshuffles When only 10000 people is left alive.
  15. World Destroyed!


You can follow the Strategy above but you will be lacking DNA, So Choose Symptoms Wisely. And you must use patho-stasis For the Fungal Spores.

I cannot find a proper strategy for Prion, Nano-Virus and Bio-Weapon. And sorry for the poor English.

If the strategy’s does not work, use the most noob strategy. Don’t let symptoms mutate (Use the Translation + gene) and Wreak the world when All people infected.

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