Plague Inc. Wiki
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The following are strategies for the Prion plague type. Please read the Wiki Rules, before adding a strategy, tips and Q&A here. If you aren't quick enough to devolve a mutation before it's spotted, then pause the game time, then devolve the mutation.

Strategy 1

Recommended Genetic Code:

  • Catalytic Switch:That way when you blow your cover you have a steady DNA source.
  • Genetic Mimic: More time to kill the humanity
  • Aquacyte: Island countries like Greenland, Iceland and such will be easier to infect.
  • Extremophile: An slight boost in any environment is always nice to have.
  • Patho-stasis: Less DNA expended in the abilities.
  1. Start in a hot country (India, for example)
  2. Evolve in order: Water 1, Air 1, Water 2, Air 2, Cold Resistance 1, Drug Resistance 1, Extreme Bioaerosol, Drug Resistance 2, Neural Atrophy 1, 2 and 3.
  3. Devolve any mutated symptoms.
  4. When all the countries are infected, evolve Coughing to speed up infection.
  5. Wait until every human is infected.
  6. When "There`s no healthy people" pop up appears evolve (in order): Genetic Hardening 1, Pneumonia, Pulmonary Fibrosis, Total Organ Failure, Immune Suppression, Fever, Skin Lesions, Necrosis and Genetic Hardening 2.
  7. IF the cure goes too high, evolve Genetic ReShuffles as needed.
  8. (Optional) Evolve Insomnia, Paranoia, Seizures, Coma, Paralysis and Insanity to slow down the cure.
  9. Wait until your plague kills everyone.

Strategy 2

This is a simple strategy which will work on Casual, Normal or Brutal (This doesn't work on Mega Brutal because the 'random medical check-ups' make the disease noticed and a cure is available before everyone is infected.

Genetic Code

DNA Gene: ATP Boost or Metabolic Jump

Travel Gene: Aquacyte or Suppression

Evolution Gene: Ionised Helix

Mutation Gene: Genetic Mimic

Environment Gene: Extremophile... or anything really

Stage 1: Begin

Step 1. Start anywhere... the best places are India, Saudi Arabia, Greenland, Egypt, Madagascar or even Norway!

Step 2. Fastforward

TIP 1: If any symptoms evolve DEVOLVE THEM IMMEDIATELY!!! Doctors will spot the disease and the Cure Research will begin. In the future the cure percentage will already be too high to avoid.

TIP 2: If you started in a heated climate area and noticing that infecting the population in cold climate areas (Canada, some countries in Europe) are extremely slow, then you can evolve Cold Resistance 2 at Step 6.

Stage 2: Infection

Step 3. Evolve Air 1 and Water 1

Step 4. Evolve Cold Resistance 1 or Heat Resistance 1; the opposite climate of your starting country. (e.g. if you started in Egypt you would evolve Cold Resistance 1).

You should be gaining DNA Points by now. Make sure you save them up for later though!

Step 5. Evolve Air 2 and Water 2.

Step 6. Evolve Insect 1 and Extreme Bioaerosol.

Your disease should be spreading like wildfire now! When you get the message 'No more healthy people left in the world', you know it's time!

Stage 3: Exterminate

Step 7. Devolve all Transmissions for extra DNA Points

Step 8. Evolve the following in order:

You should've had enough for all of those because if you popped all the red and orange bubbles and devolved all symptoms you should have at least twice the amount you needed. Paranoia is the most important because it will stop people from seeing the doctor.

Step 9. Evolve Genetic Hardening 1, Genetic ReShuffle 1 and Genetic Hardening 2

Step 10. Evolve

Watch as the last few people hopelessly die. Watch as the screen with the words 'Victory! *your disease name here* has successfully eliminated all life on earth. You Win.


This strategy was made by Terra Verso

This strategy does not work if you use the mobile version.


This does indeed work on mobile but these things are needed:

and maybe:

Also, I am not sure if these two help, but I used them when I tried so I am including them.

When the ICure device message came up, I evolved Rash and Sweating.

You are welcome to try it without it.

Strategy 3

You need to evolve some nonlethal symptoms in order to get more DNA from the bubbles. (aggressive approach works better due to slow infection rate of prion, making stealth approach much harder in higher difficulties. Feel free to pick any genes that suit you, as the original author succeeded with this strategy in mega brutal with no genes)

Wait until every island (country) is infected, and wait for Greenland and Iceland to be about 50% infected.

This should work in mega brutal as well, even if you have no genes

This strategy works on mobile the best out of the three.

This strategy is courtesy of Milkyway_Squid from reddit (added info is italicized)

Strategy 4

strategy by Vincent Conti

Recommended Genes: ATP Boost, Aquacyte, Sympto-stasis, Genetic Mimic, Extremophile

1.Start in Argentina.

2.Evolve these transmissions: Livestock 1, Livestock 2, Bird 1, Water

3. Evolve Nausea, Coughing, Rash, Insomnia, Cysts, and Anaemia.

4. Evolve Bird 2, Air 1, Air 2, and Extreme Bioaerosol.

5. Evolve the following:

• Vomiting

• Pneumonia

• Sneezing

• Sweating

• Paranoia

• Abcesses

• Hyper sensitivity

These will greatly increase your infectivity and severity.

6. Evolve Cold Resistance 1, Heat Resistance 1, and Drug Resistance 1.

7. When around half of the world is infected, evolve the following:

• Diarrhoea

• Immune Suppression

• Necrosis

• Systemic Infection

• Seizures

• Insanity

8. Evolve Genetic Hardening 1.

9. When almost all of the world is infected, evolve extremely lethal symptoms:

• Dysentery

• Total Organ Failure

• Hemorrhagic Shock

• Internal Haemorrhaging

• Tumours

10. Use slowing cure symptoms: Coma, Paralysis

11. Use your remaining points on Genetic Reshuffles and Neural Atrophies.

NOTE: If an island country closes its ports, restart.

Strategy 5

no genes brutal challenge

  • evolve Cold Resistance 1,2
  • evolve Skin Lesion to improve infectivity
  • (your disease will be spotted after a while, but no worry and keep developing)
  • Be cautions not letting severity for too high, since countries can shut down ports
  • Countries will start focusing on cure. Evolve Insomnia chain and go for Insanity

(Coma is OK but it requires more DNA)

  • evolve Genetic Reshuffle1 if necessary

(Urban counties should be full filled with infected. If you got trouble in rural countries, go for live stocks

(Warning: do not devolve Necrosis in any other cases when the whole world hasn’t been infected

  • Watch the whole world die, if you’re cautious evolve more disturbing symptoms such as Coma
  • Good Luck!


  • The Prion behaves similar to Parasite, except for the fact that it doesn't have any abilities to reduce severity, which is a key stat in Plague Inc. when players are choosing a more stealthy approach. This means that any new symptoms added cannot have their severity levels suppressed, thus forcing the player to decide carefully when evolving.

Prion is extremely deadly even though it has a low severity rate. Still, it's possible to have a prion with a high severity rate if caution is not being taken into account. - Dan67

Strategy guides in Plague Inc. and Plague Inc: Evolved.
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