The following are tips and strategies for the Parasite plague type. Please feel free to add your own strategies, tips, and Q&A here:

Strategy 1Edit

1). Use any Genes that can help the parasite increase infection or add genes that help the Parasite in ways like increased transmission on planes.

2). Avoid Starting in a Rich Nation instead try to infect the poor countries with a high population density like China, Libya and Mexico

3). By evolving all three steps of its special ability before anything else, Severity plummets. Parasite is very stealthy and it's not difficult to infect the entire world without the cure even starting.

4). If a stealth approach was taken without alerting any of the countries then proceed to infect the world with lower tier symptoms such as Coughing, Sneezing, Nausea avoid using the sweat symptom if a headline pops up for it which can make curing and noticing the disease easier with said symptom.

5). If you have successfully infected the entire world without being detected then evolve Total Organ Failure but make sure all nations are infected before purchasing this symptom especially on Mega Brutal difficulty. - Dan67

Strategy 2Edit

So this strategy worked amazingly well for me - in fact I ended up better off in Brutal than in Casual or Normal.

Now just wait and pop the red and orange bubbles - devolve any symptoms that mutate (and collect that lovely bonus).

  • You will find initial spread and DNA accumulation will be slow, but will rocket at the end.  If you want to speed it up, put Bird 1 in place.
  • By the time the whole world is infected, you should be looking at 140+ DNA.... if you hold on until the end (i.e. 100% infection), you can now devolve all of the transmissions for bonus DNA.
  • Evolve Genetic Hardening 1 2 and then get the symptoms as deadly as you choose - Up to Total Organ Failure through Cysts is good as it takes in Coma to slow the cure... if you have enough DNA you can get down from Fever to Necrosis too....
  • Sit back and watch the world die.... as you get the DNA you can either do Genetic ReShuffle 1, 2, or 3 to slow the cure, or get more and more deadly symptoms. - Unknown

Strategy 3Edit

This is a simple strategy which will work on Casual, Normal or Brutal (This doesn't work on Mega Brutal because the 'random medical check-ups' make the disease noticed and a cure is available before everyone is infected.

Genetic CodeEdit

DNA Gene: ATP Boost or Metabolic Jump

Travel Gene: Aquacyte or Suppression

Evolution Gene: Ionised Helix

Mutation Gene: Genetic Mimic

Environment Gene: Extremophile... or anything really

Stage 1: BeginEdit

Step 1. Start anywhere... the best places are India, Saudi Arabia, Greenland, Egypt, Madagascar or even Norway!

Step 2. Fastforward niblet

TIP: If any symptoms evolve DEVOLVE THEM IMMEDIATELY!!! Doctors will spot the disease and the Cure Research will begin. In the future the cure research will be too much!

Stage 2: InfectionEdit

Step 3. Evolve Air 1 and Water 1

Step 4. Evolve Cold Resistance 1 or Heat Resistance 1; the opposite climate of your starting country. (e.g. if you started in Egypt you would evolve Cold Resistance 1).

You should be gaining DNA Points by now. Make sure you save them up for later though!

Step 5. Evolve Air 2 and Water 2.

Step 6. Evolve Insect 1 and Extreme Bioaerosol.

Your disease should be spreading like mad now. When you get the message 'No more healthy people left in the world', you know it's time!

Stage 3: KillEdit

Step 7. Devolve all Transmissions for extra DNA Points

Step 8. Evolve the following in order:

You should've had enough for all of those because if you popped all the red and orange bubbles and devolved all symptoms you should have at least twice the amount you needed. Paranoia is the most important because it will stop people from seeing the doctor.

Step 9. Evolve Genetic Hardening 1, Genetic ReShuffle 1 and Genetic Hardening 2

Step 10. Evolve

Watch as the last few people hopelessly die. Watch as the screen with the words 'Victory! *your disease name here* has successfully eliminated all life on earth. You Win.


This strategy was made by Terra Verso

Strategy 4 (for Mega Brutal) Edit

This is only for the patient player!

  • DNA suggestions:

ATP Boost, Teracyte, Trans-Stasis, Base Hydrolysis (!), Hydrophile

  • Start in the US (I'm serious: only the US can contain a plague long enough to give you the time you need before being discovered)
  • Develop ALL infections tiers 1+2. DO NOT get layer 3, you will be discovered too soon.
  • Keep popping DNA bubbles. It will take VERY long to get the necessary points
  • Devolve any symptom (always have some points in reserve for this, it's essential)
  • Let all abilities mutate except for Drug Resistance. If is mutates, devolve it, even if it costs you.
  • Make sure you have Cold Resistance 1 and 2 and Heat Resistance 1 before you make your move.
  • Wait.
  • Wait.

If anything happens to boost your plague, you must either hurry or restart (Love Festival, spreading too soon...).

  • When all tier 2 abilities are developed, save up: enough for Extreme Zoonosis and Extreme Bioaerosol, Drug Resistance 1, some symptoms.

Then it gets harder: unleash tier 3 symptoms and Genetic Hardening 1, Coughing, Pneumonia, Pulmonary Fibrosis

  • Develop towards necrosis then.
  • When the whole world (or at least 90%!) are infected, unleash *Total Organ Failure. You might have to counter the cure, but usually things go down quickly.

When you have points left, go for Coma, but keeping the cure down is more important.

It takes time, and you might fail once or twice, but it works. Developed by Torek

Strategy 5 (for Mega Brutal) Edit

Parasite is poorly designed for Mega Brutal, because the fastest and most consistent way to win is by entirely ignoring the Symbiosis special ability, resulting in a strategy that similar to Mega Brutal Bacteria. Game ends around ~450 days.

Recommended Genetic Code:

  • Metabolic Jump - A must have! Bio-hazard bubbles spawn a lot more predictably than DNA bubbles, and most will spawn in the late-early game/mid game when you need DNA the most. I've seen +5 DNA from a single Bio-hazard bubble before, resulting in much more DNA available overall.
  • Genetic Mimic - Highly recommended for any Mega-Brutal mode game.
  • Aquacyte - Makes infecting isolated islands like Greenland, New Zealand, Caribbean easier.
  • Extremophile - Nice to have but others like Xerophile are fine too.
  • Sympto-Stasis - Useful to ensure end game symptoms don't cost too much DNA.

Preferred Starting Location: Saudi Arabia

Step 1: Initial Symptoms

Mega Brutal mode requires an aggressive strategy to defeat the cure timer. Higher severity increases the chance of getting more DNA from orange DNA bubbles, but the player needs to balance that against attracting too much attention early on. Take the following symptoms:

If the Festival of Love event fires, pick up Nausea. If the air or ship filtration event fires, pick up Air 1 or Water 1 respectively.

Step 2: Spreading Your Parasite

Prepare the parasite for global transmission with the following traits:

Step 3: Prepare for Resistance

By this time, the parasite should have been spotted by the world or will be shortly. Slow down their research efforts with the following traits:

Step 4: Endgame

About two-thirds of the world should be infected by this stage. Maximise infectivity to finish global infection and begin killing to generate DNA with these traits in order:

Use Genetic ReShuffle 1/2/3 as required. Top up infectivity with non-lethal symptoms like Diarrhoea, Pulmonary Oedema, Sneezing until the rest of the world is infected, at which point use Total Organ Failure.

Developed by Atua101.

Strategy 6( Up to brutal) Edit

A strategy for up to brutal.(Cannot work for mega brutal due to Genetic drift AND that they detect the virus really early on ;-;)

Genes: Metabolic jump/cytochromic surge, Aquacyte,Sympto-statis(you will see why later), Genetic mimic(MUST HAVE), extremophile)

1:Start in India.

2:Get symbosis 2, and air and water 1. Get drug and cold resistance one too. Prioritize Air/water if they get filters, otherwise get symbosis 2 first.

3:Allow it to mutate, if lethal synptoms like diarrhea appear, devolve .

4: Get Air 2, Water 2, Bird 1, Insect 1. Get drug resistance 2 and symbosis 3. If you have troubles with cold countries like greenland, get cold resistance 2 as well. 

5:Wait, and save up dna points. Allow it to mutate, unless the synptoms kill. Mostly, the severity should  remain at 0 until the next 2 steps

6: Once you infect the world, get Total Organ Failure. Devolve certain transmissions(until you do not get dna points). Also get insomnia and paranoia

7: Get Hemorrhagic Shock. Also get insanity, paralysis and coma  if possible.

8: Laugh as the world collapses.

Note: Catalytic switch is not advised, as too little dna is got.( At most only 8 bubbles appear.) Translesion+ is not used, because synptoms will cost too much. This can affect play if Genetic Reshuffle cost too much, yet you cannot get paranoia, insomnia and paralysis. I have not tested ATP boost, so you can test it.

This strategy works on brutal.


  • The Parasite is a manageable plague type for both new and veteran players as it does not mutate frequently like other plague types do, thus giving players a huge stealth advantage at the beginning of the game, especially with the Symbiosis abilities. However, the parasite is slow to adapt meaning that increasing lethality early in the game could put it at risk unless multiple nations have already been infected heavily by the parasite.

Focus on Drug Resistance and  Genetic Hardening, then proceed to mutate transmissions, which allows the parasite to spread its infection while being under the radar. - Dan67

From what I know Strategy 2 & 3 don't work. The cure comes out too quickly. - User:Terra Verso

Proven and tested! Strategy 3 works fine and good. Tried it and ended at 87% cure. But one thing, if you've evolved all lethal symptoms and there is/are countries not infected completely, devolve the lethality. Let infection infect the entire world. And after infection, your DNA points bursts like madness. And kill 'em all. - User: DoctorPhD

Strategy 5 is solid. Got 4 biohazards on Mega Brutal on my first try without needing any genetic reshuffles, only had one mutation (hemorrhagic shock, very late game), and cure was only at 47%. - User: Zulera301


Strategy guides in Plague Inc. and Plague Inc: Evolved.
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