Strategy Guides
The following are strategies for the Bacteria plague type. Please read the Wiki Rules, before adding a strategy, tips and Q&A here. If you aren't quick enough to devolve a mutation before it's spotted, then pause the game time, then devolve the mutation.

Strategy 1

Starting Off

(For normal/brutal difficulties; works on casual as well)

Start in West Africa. Do not buy anything until you have acquired over 51 DNA Points.

Once you have accumulated over 51 DNA points, buy the following Transmissions and Abilities in order:

  1. Water 1 (9 DNA)
  2. Bird 1 (13 DNA)
  3. Air 1 (11 DNA)
  4. Drug Resistance 1 (11 DNA)
  5. Bacterial Resilience 1 (7 DNA)

For a total of 51 DNA Points.

As your Bacteria starts to spread, devolve any mutations you receive.

If you get a message that says a place has added more security,  such as 'USA bans movement of livestock,' upgrade the corresponding upgrade in transmissions (in this case, livestock). Such instances, however, shouldn't occur if you follow this strategy—as long as you don't get the disease spotted. But if a random event happens like a rural livestock legislation, disregard that last sentence and be ready for an American livestock stasis.

Mid game - Infect the rich and protect yourself

Upgrade the following to infect more people:

For a total of 62 (Without Genetic ReShuffle 1) or 86 (With Genetic ReShuffle 1) DNA points

End game - killing time

Use this path to quickly achieve Total Organ Failure (Accumulate 47 DNA points to get all of them quickly and no risk of failure):

  1. Coughing (4 DNA)
  2. Pneumonia (4 DNA)
  3. Pulmonary Fibrosis (8 DNA)
  4. Total Organ Failure (31 DNA)

For a total of 47 DNA points.

Strategy 2

You get most infection for the money from the symptom Coughing. Having only Coughing will not lead to the disease being discovered as long as you devolve any other mutated symptom, and the mystery plague event doesn't happen.

1. Start in India

2. Get Coughing

3. Get Water 1 and 2

4. Get Air 1 and 2

5. Get Bacterial Resilience 1 and 2

6. Get Drug Resistance 1 and Cold Resistance 1

7. Improve resistances further, if for example Iceland or Canada is especially slow to infect, and you have a lot of DNA. Otherwise be patient and save the points for the kill strike and slowing research.

8. When all are infected, get killing symptoms. The strategist used the same tree as in the commented guide.

9. Immediately buy both abilities slowing future research. If you have points left now, invest more in lethal symptoms like Hemorrhagic Shock to kill faster.

10. At the end, buy all abilities increasing the amount of research needed, as well as the symptoms Coma and Paralysis. This will decrease the percent research completeted, and give you more points for the win. If you still have points left, invest in symptoms with maximum severity and infectivity as this may give some more points.

The key is fast and unnoticed transmission, followed by swift kill and decreased researched speed, and in the end lowering the percentage of the completed research.

Get higher score by winning faster with less cure research completed, and as severe disease as possible.

Strategy 3



ATP Boost

Genetic Mimic




1. Start in China Note: Evolve the upgrades AS SOON AS POSSIBLE!

2. Evolve the following IN ORDER! (Devolve any irrelevant symptoms) Water 1

Insect 1










Hyper sensitivity



(This should be every stage 1 + 2 symptoms)

3. Now evolve IN ORDER Water 2

Insect 2

Bacterial Resilience 1

Bacterial Resilience 2

Bacterial Resilience 3

Drug Resistance 1

Drug Resistance 2

Goodbye Canada!

4. Now for some infective symptoms! Skin Lesions



Necrosis - Optional

5. Stop the cure!

Genetic Hardening 1




Note 1: If an island closes ports before you infect it, restart

Note 2: If cure goes >90%, get Genetic ReShuffle 1

6. Wait for world to get infected

Note: If country closes land borders before infected get Bird 1

7. Evolve killing symptoms and cure slowing symptoms

Total Organ Failure

Collect DNA from killing people

Coma - To slow the cure

Hemorrhagic Shock

Get more genetic reshuffles if the cure is too high and try some more symptoms if you're too impatient!

Internal Haemorrhaging

Systemic Infection

Immune Suppression

8. Watch as the world is quickly ummm... plague-ed to death?

Strategy 4

This is a simple strategy which will work on Casual, Normal or Brutal (This doesn't work on Mega Brutal because the 'random medical check-ups' make the disease noticed and a cure is available before everyone is infected.


DNA Gene: ATP Boost or Metabolic Jump

Travel Gene: Aquacyte or Suppression

Evolution Gene: Ionised Helix

Mutation Gene: Genetic Mimic

Environment Gene: Extremophile... or anything really

Stage 1: Begin

Step 1. Start anywhere... the best places are India, Saudi Arabia, Greenland, Egypt, Madagascar or even Norway!

Step 2. Fastforward

TIP: If any symptoms evolve DEVOVLE THEM IMMEDIATELY!!! Doctors will spot the disease and the cure research will begin. In the future the cure research will be too much!

Stage 2: Infection

Step 3. Evolve Bacterial Resilience 1

Step 4. Evolve Air 1 and Water 1

Step 5. Evolve Cold Resistance 1 or Heat Resistance 1; the opposite climate of your starting country. (e.g. if you started in Egypt you would evolve Cold Resistance 1).

You should be gaining DNA Points by now. Make sure you save them up for later though!

Step 6. Evolve Air 2 and Water 2.

Step 7. Evolve Insect 1 and Extreme Bioaerosol.

Your disease should be spreading like mad now. When you get the message 'No more healthy people left in the world', you know it's time!

Stage 3: Kill

Step 8. Devolve all Transmissions for extra DNA Points

Step 9. Evolve the following in order:



Pulmonary Fibrosis

Total Organ Failure



Devolve Insomnia

Evolve Coma

You should've had enough for all of those because if you popped all the red and orange bubbles and devolved all symptoms you should have at least twice the amount you needed.

Step 10. Evolve Genetic Hardening 1, Genetic ReShuffle 1 and Genetic Hardening 2

Step 11. Evolve



Internal Haemorrhaging

Hemorrhagic Shock

Watch as the last few people hopelessly die. Watch as the screen with the words 'Victory! *your disease name here* has successfully eliminated all life on earth. Watch as you leap up into the air and scream 'YES!!! THANK YOU TERRA VERSO!!!' Drop your device and then realise that it was just Bacteria on Casual.


(as mentioned earlier)

This strategy was made by Terra Verso

Strategy 5

Works in Casual, Normal and Brutal.


DNA: Cytochrome Surge

Mutation: Genetic Mimic

Travel: Aquacyte

Environment: Extremophile

Evolution: Patho-Stasis

Stage 1: Infection

Start in Saudi Arabia.

Evolve Bacterial Resilience 1, Bacterial Resilience 2 and Bacterial Resilience 3, Cold Resistance 1 and Cold Resistance 2, Heat Resistance 1 and Heat Resistance 2, and Environmental Hardening in that order.


Evolve Drug Resistance 1, then Genetic Hardening 1 and Genetic Hardening 2. If Air filters or New Ship Cleaning Teqniques come into effect, evolve the respective Transmission.

Evolve Drug Resistance 2

If at any point people find your disease, evolve as many tier 1 or tier 2 symptoms as you like for that sweet, sweet DNA, and you should also allow all mutations.

Stage 2: Killing

Wait for all countries to have at least 100 people infected.

Evolve Skin Lesions (if you don't have it already), Necrosis, Hemorrhagic Shock and up to Coma through Total Organ Failure

Watch the world burn.

If at any point the cure reaches over 75% completion, evolve the next Genetic Shuffle ability.

Strategy 6

This strategy works well on Mega-Brutal difficulty

  1. Choose Sympto-Stasis, Aquacyte, Catalytic Switch, Genetic Mimic, any environment gene. Start in Saudi Arabia
  2. Evolve Cysts, Abscesses, Rash, Sweating and Skin Lesions in any order.
  3. Evolve Coughing, Pneumonia, Sneezing, Hypersensitivity, Insomnia, Paranoia, Nausea, Vomiting and Diarrhoea in any order.
  4. Evolve Air 1, Air 2, Water 1 and Water 2 in any order.
  5. Evolve Heat 1, Cold 1, Cold 2, Drug Resistance 1, Necrosis and Drug Resistance 2 in any order.
  6. When Greenland is infected, evolve Dysentery, Anaemia and any symptom that isn't too lethal.
  7. When greenland is nearly infected, evolve more lethal symptoms
  8. Evolve the genetic reshuffles.


Start in Saudi Arabia. It has a major airport and seaport network. However, it is not rich, meaning it will not use medicine. Your disease will also get automatic Heat Resistance 1 and Heat Resistance 2.

Coughing and Sneezing are contagious symptoms with little severity. Recommended transmissions are Air 1 and Air 2. Get Cold Resistance 1, Cold Resistance 2, Drug Resistance 1, and Drug Resistance 2, as well as Water 1 and Water 2 once you get to rich, wealthy, cold, and humid countries, such as Europe.

At this point, you are good to go. Once Greenland and the rest of the world is fully infected go for lethal symptoms. The most powerful of them should be Total Organ Failure. Once the Cure is around 30%, go for Genetic Hardening 1, Genetic Hardening 2, Genetic ReShuffle 1, Genetic ReShuffle 2, and Genetic ReShuffle 3.

And you have eradicated humans.


  • Make sure that your bacteria's infectivity is more than lethality. Sometimes, people die faster than more people are infected (you sometimes get an alert about that). Then not enough people are infected and those who are, die really fast along with the bacteria, ending your disease's reign.
  • Start in Greenland, Oceania, Madagascar, Canada, Saudi Arabia or China. The first three are hard to infect, the fourth has free healthcare, and the last two are just a good, all around place to start!
  • South Africa is good starting point. It has both a seaport and an airport. It will spread to other countries quickly. Also using insect and air as your primary transmissions is a good strategy there. Try to evolve the Insomnia symptom tree when you need to kill.
  • The UK/France are good starting locations since they have active ports and airports, they're close to Greenland and they have large populations. The UK also gives the small cold resistance buff.
  • Try Saudi Arabia; there is lots of traffic there and it is almost in the middle of the map. Use Air and Water transmissions to infect countries by air, and Madagascar, one of the hardest countries to infect, by sea. Also use insect transmissions and heat resistance to spread faster here.-
  • Egypt's not a bad starting place. Urban, 2 seaports and an airport. Also, you can use Insect 1 and it spreads insanely with Air 1/Water 1. -
  • Hey, try China. Well balanced climate there. - Thepeashooter100
  • So is Madagascar!. (I recommend starting in poor countries because you won't have to get Drug Resistance 1, like Madagascar) -
  • India is a very good starting point. -
  • Remember, the larger the country, the more people that must be infected to have a chance of spreading to other countries. In my opinion, Saudi Arabia is best. - MLG.LOL
  • ...Whenever the time comes to kill, Total Organ Failure and Immune Suppression are my favourites. They drop like flies. -
  • If you don't have time and have been spotted but some countries (e.g. Greenland) are holding out on you, use the anemia/rash paths. This will increase infectivity more - Skin Lesions - and greatly increase lethality as well as corpse transmission; Necrosis, Internal Hemorrhaging, Hemorrhagic Shock. = Unknown User
  • Alternatively, if the cure is bugging you, go for the left side of the symptoms tree to destroy research and begin rapid death: Insanity, Paralysis, Dysentery and Diarrhea. = Unknown User
  • For a Brutal strategy, go hereMega Brutal is hereThese are links to external guides, so please thank them if it works for you! - Insertrandomnamehere
  • When in doubt, start in Saudi Arabia. Boats go all over the place, and Planes go to every country with an airport. -
  • A country only gives you a red DNA bubble the first time its infected. Killing the only infected person in that country and infecting it again won't give you a second red DNA bubble


  • Try starting in Greenland because if it closes its borders before you infect it it is almost impossible to get inside.-
  • Try to start in China and get bird level 1 and 2 and wind level 1.


  • No matter the mode, get Drug Resistance and Genetic Hardening ASAP, before any cure research takes place. Pair it with the Walking Dead Symptom Combo to buy yourself precious time to stop cure research giants like Canada and the elusive Greenland. If they wall up before infection, its game over.
  • Staying under cover is always good. Also, what I do is select the DNA genes that are Genetic Code Darwinists and the one other that gives you extra DNA points when De-Evolving it's symptoms/transmissions/abilities. -User:THFPVG
  • Also, keep in mind: The abilities are crucial to winning in a tough climate or country like the USA. -User:THFPVG
  • Try not to fully upgrade the insomnia side. It stinks at killing people.-randomfandom
    • When you have the double start cheat, use USA and China. It's very useful,especially because those country are huge,and they have a lot of airports. They're a great place to begin.Also, be careful with Oceania, Caribbean, Island and Greenland.They're often hard to infect. - User:CannibalCarrot

User:Unknown User

  • Evolve transmissions first. Drug Resistance 1 should be evolved when asked. Once the world is infected, Evolve symptoms like no tomorrow!
  • for me, Russia is the best place to start

The strategy below was made by: SomeRandomPolandBaller

This works in Casual, Normal, and maybe Brutal

  • Start in China
  • Build to 20 DNA
  • Evolve some transmissions like Water I and Air I
  • Devolve ANY mutated symptoms
  • Build to 50 DNA
  • Complete the Water-Air tree
  • Build to 20
  • Evolve Bacterial Resilience and Drug Resistance
  • Wait for the world to be infected, save up to 47
  • Then, after the world is infected, evolve all the way up to Total Organ Failure for a cost of 47 DNA
  • Build up all you want, evolve any symptoms you like
  • Now kill off the world


Seven Claps is not my YT channel, someone vandalized my strategy

If you can't complete the Water-Air Tree, build up your DNA again

- SomeRandomPolandBaller


  • Why always India? Are you guys like,racist to them? -
    • It's not our fault they provide the perfect starting area! I mean, come on, they're rural, humid...all of the good conditions to target with a transmission. Insect, Water, Air, and Livestock. Spectacular. The best part? There's a BILLION of them in one country! 1/7th of the world's population! AND the country with the world's highest population (in the game at least) -Tjmachado
Strategy guides in Plague Inc. and Plague Inc: Evolved.
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