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The following are strategies for the Prion plague type in the Cure Mode. Please read the Wiki Rules, before adding a strategy, tips or Q&A .
If you want to write new strategies, please use this page.

Strategy 1[]

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Basic Information

  • Author: FallenThePro
  • Difficulty: N/A
  • Note: 100% success rate, I tried for 7 times and it all worked. Do not reduce fatality rate because it is infinity and the bar will keep full.

Gameplay

  1. Set up your base in Saudi Arabia and fund Investigate Outbreaks and Government Partnerships and Deploy Field Operatives.
  2. Send the base to Brazil, USA, Canada, Germany, Russia, C. Africa, China and Australia.
  3. The disease should be found and then fund Rapid Analysis
  4. Wait for analysis to finish
  5. Fund Extend Incubation 1 and 2, Reassure Infected 1 and 2, Vaccine Research.
  6. Fund Neuro Enhancers.
  7. Fund Accelerated research, Vaccine Manufacturing, Accelerated Manufacturing.
  8. Use all sort of stuff to reduce Infection rate and Compliance Risk
  9. The world should be infected a lot. then when most countries infected, lockdown the whole world.
  10. deal with all sorts of Authority loss and wait for the Vaccine to be done plus starting to be released to the world.
  11. Refund all Quarantine stuff to buy Authority 1-3 and censorship (If censorship ends before disease eradicated, buy fake news.)
  12. You cured the disease and now.

Strategy 2 (Mega Brutal, Mobile)[]

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Basic Information

  • Author: VillagerVicky
  • Difficulty: Mega Brutal
  • Note: I don't know why but strategy 1 doesn't work for me. This strategy looks very crazy but does work.
  • Success rate: ~70%

Task Force

  • Forensic Epidemiologist
  • Celebrity Scientist
  • Strategic Fundraiser
  • Fast Response EMTs
  • Medical Coordinator

Gameplay

  1. Start in Greenland and fund Investigate Outbreaks and Government Partnerships and Deploy Field Operatives.
  2. Send the base to Canada, USA, Brazil, West Africa, South Africa, Australia, India, China.
  3. (*) If you've found the prion before you finish 2, go to its surrounding countries and the "red line" countries.You should investigate as many countries as you can before the analysis is finished.
  4. After you find the prion, fund Rapid Analysis.
  5. If Europe is infected, lock its seaport to protect Greenland.
  6. Wait for analysis to finish.
  7. Go to the origin country.
  8. Fund Extend Incubation 1&2 and Vaccine Research.
  9. Fund Neural Enhancers.
  10. Fund Accelerated research, Field Research and Global Research Treaty.
  11. Fund Vaccine Manufacturing, Accelerated Manufacturing and Global Manufacturing Treaty.
  12. Fund Authority 1.
  13. If the Non-Compliance is too high, fund Furlough Schemes.
  14. As soon as it becomes lethal, fund Censorship.
  15. Fund Fake News as soon as Censorship expires.
  16. When Vaccine Manufacturing reaches 70%, fund Bypass Safety Measures. (If the factory explodes, restart)
  17. Fund Reassure Infected 1&2 as soon as Fake News expires.
  18. Fund Authority 2&3 if you can.
  19. The world is saved!

Strategy 3[]

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Basic Information

  • Author: Zavarian
  • Difficulty: Mega-Brutal (Mobile Version)
  • Success Rate: N/A (This gameplay is being lucky and hoping death reports are late and there's no bottleneck of vaccine, but it has a great success rate if played by this luck. It might take many more restarts but it works.)

Task Force

  • Disease Advisor: Forensic Epidemiologist
  • Quarantine Advisors: Quarantine Coordinator
  • Outbreak Advisors: Technical Officer/Strategic Fundraiser (I chose Technical Officer because I was limiting the spread of the prion but you can choose fundraiser if you want because you'll need lots of funds for this strategy to work.)
  • Field Advisor: Fast Response EMTs
  • Operation Advisors: Medical Coordinator

Gameplay

  1. Start anywhere you want if you chose a technical officer as your advisor, but I suggest near rich countries. If you just chose a strategic fundraiser, then start somewhere you think it'll be the last place the prion will reach (probably Greenland or the Caribbean)
  2. You know the gist, fund the three (Investigate Outbreaks, Government Partnerships, and Deploy Field Operatives)
  3. Visit many rich countries as possible as you also look for the prion. If you find it, fund rapid analysis and then continue visiting rich countries and maybe China and India. And also near countries near the origin country. And just collect your DNA for now, Don't bother locking down or alerting any continent, it's just a waste of resources but if you chose a fundraiser and don't want to reach your continent, it's your choice.
  4. After analyzing is finished, put your operative in the origin country and hope they get the bonus of finding patient zero to get speed up the vaccine research. (If you don't find patient zero after the vaccine research is done and you still haven't lost your authority then just continue on with the gameplay.)
  5. Now all the funds you collected, probably reach maybe 30-50 resources and start funding in this possible order (Note: You don't have to follow it but get it in the future if possible.)
    • Vaccine Research
    • Accelerated Research
    • Global Research Country (Conclusion: visiting rich countries may speed up the research with their resources.)
    • Neural Enhancers
    • Extend Incubation 1
    • Disinfectant Supplies
    • Extend Incubation 2
    • Authority 1 (Fund Censorship if death is reported)
    • Vaccine Manufacturing
    • Accelerated Manufacturing
    • Global Manufacturing Treaty
    • PPE Package 1, PPE Package 2
    • Improve Supply Chains (to Speed up Vaccine Manufacturing, This must be done before the vaccine research is finished or else it won't work.)
  6. While you fund this, be vigilant on death reports and ready to fund censorship 1 or 2 if deaths haven't been reported. If vaccine manufacturing is 70% above or you're running out of time in censorship but almost finish with vaccine manufacturing, then fund Bypass Safety Measures too, and if it works and the vaccine is completed before censorship runs out, You Win!
  7. Also, fund Authority 2 and 3 if you still have funds left, while the vaccine almost near being release the authority still drops (I had 21 authority after the vaccine was completed but still drop to 18 while releasing it. The Devs should probably fix this.)

Strategy 4 (Mega-Brutal, PC Version)[]

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Basic Information

  • Author: RayCharlZ
  • Difficulty: Mega Brutal
  • Note: The principle is to not focus on the cure before you control the infection rate, but still reassuring people that they won't die, which is plain false. It takes several attempts but works on mega brutal without any task force. You will first reduce the infection with lockdowns, then use all infection prevention responses.

Gameplay

  1. Start anywhere
  2. Fund Investigate Outbreaks, Government Partnerships and Deploy Field Operatives as fast as possible . You don't have to wait for a country to be revealed to send it somewhere else, you just need the plane to have landed.
  3. As soon as you have found the patient zero country, Force Lockdown on the continent (do not close accesses) and get all the compliance boosts. Reveal all the countries around it for free funds thanks to the bubbles.
  4. Take Infection Control and send your operatives in the patient zero country. It should have less than a million infected people.
  5. Start taking Infection Prevention responses together with Contact Tracing. Your goal is to get all of them while performing 6., 7. and 8. Local Lockdowns should be the last thing you pick as it decreases compliance.
  6. As soon as a continent has around 100,000 infected people, Force Lockdown on it. You must have all the compliance boosts at this stage.
  7. Take Reassure Infected 1 as soon as you start losing points because of people panicking (you can see it in the world recap). Do not take the level 2, it is useless.
  8. People should start dying. You will lose a good chunk of authority from this and the infection spread, but you should... survive. You will probably need to use Authority 1, 2 and 3 to tank the damages. Do not use Censorship unless you do not have any other choice as it decreases compliance.
  9. Now that you have the infection under control, develop the vaccine.
  10. Send your operatives in the most infected country. The world tab helps to find it, but don't send them to countries with a low population as they don't cost you much Authority.
  11. At some point, there will be countries with 10 infected people. That seems to never go below this number and people will start to revolt. However, you should have a lot of money so invest in Targeted Economic Aid and Debt Relief to shut them up. This will refund you with the lost Authority from these countries.
  12. Maintain this state until you win with the vaccine!

Gallery

Prion Cure Mega Brutal

Results (French Interface)

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