The Standard Plagues are the plagues available to the player when they first play the game. The first playable Standard Plague is Bacteria. In order to unlock the next plague type, the player must beat the plague they've most recently unlocked on Normal or higher difficulty. Each plague comes with its own abilities, strengths, weaknesses, and even its own playing style. For example, the Bio-Weapon is meant to be a fast-paced disease, whereas one can afford to be more cautious when using Parasite.
- Three of the Standard Plagues of Plague Inc. were present in the game Pandemic 2. They are the Bacteria, Virus, and Parasite plagues.