Plague Inc. Wiki
Scenario shut down.png "Recent health scares from SARS, H5N1 and H1N1 raised awareness of how quickly disease can spread. Governments are extremely concerned about the international spread of disease and people around the world are demanding that countries take pre-emptive action.
Can the world be infected before countries shut down everything?"

— Plague Inc., Shut Down Everything introduction paragraph.

Shut Down Everything is a scenario in which countries are trying to preclude the spread of diseases after people are demanding so. The player must infect all countries before the world shuts down all airports and seaports, and land borders are closed earlier than they normally would be.

Differences and advantages

In this scenario, countries will randomly shut down all land borders, airports, and seaports due to fear that an epidemic will leak into the country and destroy it. While this makes winning with the regular plagues very challenging, the special plagues are not as affected. Also, Madagascar gains three new research facilities, giving it a total of 7.

Strategies for infecting countries with closed ports and borders

This scenario is extremely easy with the Shadow Plague because the virus will not be detected until it has been released to the public through Shadow Blessing. The only problem are the Templars, as they will be abnormally stronger than usual, due to the faster militarization and faster increases of resistance. Blood Rage can be used multiple times to counter the Templars without triggering a Cure Effort. Also, combining Therianthropy with abilities such as Dark Cloud can be used to infect countries that have blocked access.

This scenario is also very easy with the Neurax Worm, due to the Trojan Planes, which can still infect countries that have already shut down all entrances, rendering the stipulation of this scenario useless. No lockdown countermeasures can withstand a Trojan Plane. As well as this, if you can use the symptoms that reduce severity and have violent Trojan passengers, you can remove most of the research capabilities that every country has, but you will be detected if a country goes to anarchism.

If you don't want to use the Neurax Worm, the gene Suppression will help the disease bypass closed borders, and the transmission Extreme Hematophagy has the chance of randomly infecting an uninfected country. Starting in Saudi Arabia also helps if you can keep your severity low until countries everywhere become infected.

In Necroa Virus, you can migrate Zombies to new, uninfected countries. Unfortunately, it'll be more difficult to gain several millions of zombies due to the plague. Just keep in mind that Z Com will still activate in this scenario, which can be a pest, as always.

Simian Flu has a unique strategy for getting around closed borders and ports. You can move apes to uninfected countries with the Travel active ability, and evolve the Transmission Hominidae Bridge to infect humans through the apes. It is difficult to do take down Island Countries this way, such as Greenland, but it is certainly possible.


In this scenario, a special event will appear, usually it will start in a very short period of time, this event will come out 100% of the time, except that it will have two variations (which are of 50% each), in the which is mentioned to the President of Madagascar or in the other variation, the Prime Minister of Greenland.

The event is basically the same for both countries, which is that the government has suddenly decided to close all entrances and exits, also decrees a permanent quarantine.

Unlike other events in this scenario, this isn't another random event because the message has been specifically written for Madagascar or Greenland.

The main reason why a Fungus or Neurax Worm is used in this scenario is because of this type of event.


Complete Shut Down Everything - Score 3 biohazards in the Shut Down Everything scenario.

Mr President - Get 3 biohazards with each disease on normal or higher in the Shut Down Everything scenario.


This scenario's title, as well as the achievement Mr President, is a reference to a meme that evolved from having to complete the difficult task of infecting the island of Madagascar in the game Pandemic 2 (which served as inspiration for Plague Inc.).

Scenarios in Plague Inc.
Diseases Scenario black death.png Black DeathFrozen Virus Scenario Logo.png Frozen VirusScenario mad cow disease.png Mad Cow DiseaseScenario nipah virus.png Nipah Virus
Scenario smallpox.png SmallpoxScenario swine flu.png Swine Flu
World Changes Scenario global health.png Created EqualScenario flight club.png Flight ClubScenario global warming.png Global WarmingScenario develop this.png Golden Age
Scenario global cooling.png Ice AgeScenario opposites world.png Mirror EarthScenario ocean piracy.png Pirate PlagueScenario financial meltdown.png Sovereign Default
Scenario shut down.png Shut Down EverythingScenario volcanic ash.png Volcanic AshScenario who cares.png Who Cares
Scenario where is everyone.png Where Is Everyone?
Other Scenario artificial organs.png Artificial OrgansScenario fake news.png Fake NewsLittle helper.png Santa's Little HelperScenario science denial.png Science Denial
Teleportation.png TeleportationScenario ubg.png Ultimate Board GamesScenario unknown origin.png Unknown Origin
Scenario xenophobia.png Xenophobia
Removed Scenario aids.png AIDS