Scenario flag@2x

Scenarios are a game mode added in the Mutation 1.7 update. It lets the player start with partially evolved, new strains of real life diseases, or play in alternate versions of the world. To complete each scenario, they must earn 3 biohazard symbols on either Casual, NormalBrutal, or Mega Brutal difficulties, but cannot unlock the next one by beating them.

As of April 22, 2014, all scenarios can be played in Plague Inc: Evolved. On iOS, players have to buy each scenario for $0.99, purchase them all for $2.99, or purchase the Plague Pack for $10.99.

List of ScenariosEdit

Name Icon Description Added in mutation

Artificial Organs Edit

Scenario artificial organs
"Rapid advances in medical science allow for the production of advanced artificial organs. As production ramps up, it is hoped that the ability to replace organs will significantly improve life expectancy.

Is humanity on the brink of immortality?"


Black DeathEdit

Scenario black death
"Patient Zero is infected with a previously dormant strain of Yersinia pestis from an unknown origin. Humanity must face a deadly bacterium that has been hidden for centuries - previously killing over 200 million people. However, the world has changed a lot in 700 years with better hygiene and more antibiotics.

Will the disease be able to adapt and spread before its victims die off?

About the Black Death (Wikipedia link)"


Santa's Little Helper Edit

Little helper
"The world is dark and gloomy. Boring governments worldwide have banned holidays, laughter, and celebrations. Humanity has forgotten how to have fun - people dress in grey and spend all their time working. Luckily, the Neurax Worm has teamed up with Santa and is determined to infect the world with joy and happiness.

Can Santa's little helper make a miracle happen?"


Created Equal Edit

Scenario global health
"People worldwide agree that a disease free world is a moral imperative. New global programme to improve surveillance capacity significantly increases ability of poor countries to identify, respond to and communicate about national disease outbreaks.

If the world stands together, nothing can stop it?"


Fake News Edit

"From wild conspiracy theories to election campaign mudslinging, we now live in a post-fact world where falsehoods and misinformation can spread around just like a disease. In this radically different scenario you'll create your very own Fake News story and shape it using all the modern tools and psychological tricks at your disposal. Can you deceive the world?

Created with the help of professional Fact Checking organisations Full Fact (UK) and Politifact (USA)"


Flight ClubEdit

Scenario flight club
"Huge leaps in aviation technology have seen humanity unlock the true potential of suborbital flight on a commercial basis. In this future world you can get from London to Sydney in 2 hours for a fraction of the cost and every country in the world has an airport. 

Does the idea of Greenland getting a major airport excite you? If so this is the scenario for you!"


Frozen VirusEdit

Frozen Virus Scenario Logo
"A giant virus, frozen deep in the Siberian permafrost, has thawed and infected an unknown victim. Dormant for over 30,000 years, it was last active at a time when mammoths and Neanderthals roamed the world. Its ancient genetic structure pre-dates Homo Sapiens but its DNA has been severely degraded.

Does it have what it takes to send humanity back to the stone age?

About the Frozen Virus (Ars Technica link)"


Global Warming Edit

Scenario global warming
"Huge releases of greenhouse gases significantly accelerate global warming and raise the global surface temperature by over 6 °C as well as triggering other climate change events and flooding of low lying countries.

Out of the frying pan?"


Golden Age Edit

Scenario develop this
"A global growth surge brings huge economic gains that primarily benefit the people at the bottom of the pyramid, improving the quality of life for billions. Healthcare and research is significantly improved worldwide.

Can humanity be stopped?"


Ice Age Edit

Scenario global cooling
"Solar variation reduces the amount of radiation emitted by the sun, triggering a minor ice age and lowering the global surface temperature by more than 5°C as well as triggering other climate change events.

Is hell freezing over?"


Mad Cow Disease Edit

Scenario mad cow disease
"Panic over BSE almost shut down the beef industry in the 1990s. Imports were banned and burgers were off the menu until humanity got things under control. Recently though, unforeseen protein folding has resulted in a new variant of the prion - putting the whole food chain at risk. Is now the time to go vegetarian?" 15

Mirror Earth Edit

Scenario opposites world
"Step through the mirror into the land of opposites where hot becomes cold and cold becomes hot, rich becomes poor and... You get the idea!

Which disease will be the fairest of them all?"


Nipah VirusEdit

Scenario nipah virus
"Rapid urbanisation in India accelerates human encroachment into animal habitats whilst a new strain of the Nipah Virus spreads fast through fruit bat colonies. Genetic crossover with other species of the Henipavirus genus could enable cross-species transmission-resulting in a Contagion worthy of Hollywood.

Could this be the most deadly Nipah outbreak ever?

About the Nipah Virus (Wikipedia link)"


Pirate PlagueEdit

Scenario ocean piracy
"Maritime piracy increases worldwide and poses a major threat to international shipping. Global sea transport and trade is significantly reduced, changing the way that people travel.

How will anyone get to Greenland now?"


Shut Down EverythingEdit

Scenario shut down
"Recent health scares from SARS, H5N1 and H1N1 raised awareness of how quickly disease can spread. Governments are extremely concerned about the international spread of disease and people around the world are demanding that countries take pre-emptive action by suicide.

Can the world be infected before countries shut down everything?"


Ultimate Board Games Edit

Scenario ubg
"Make a best-selling board game in this radically different scenario that has nothing to do with disease! Investors have given you two years to design, produce and distribute your very own game. Can your cat-themed Scrabble/Risk hybrid outsell Monopoly?" 16

Unknown Origin Edit

Scenario unknown origin
"Everyone has a favorite country, unfortunately you don't get to choose it here...

Are you feeling lucky?"


Science Denial Edit

Scenario science denial
"People around the world have stopped believing in science, medicine and even diseases. One country decides to offer scientists sanctuary and from here they hope to save humanity from itself! Can you wipe them out in time?" 16


Scenario smallpox
"Patient Zero is infected with a strain of Variola major that escaped from a lab. Humanity eradicated Smallpox over 30 years ago and has a detailed knowledge of the virus as well as powerful vaccination programmes.  

Will this be enough to stop the deadliest diseases that mankind ever known...?

About Smallpox (Wikipedia link)"


Sovereign DefaultEdit

Scenario financial meltdown
"A failure to extend the debt ceiling in the US triggers a major financial rebalancing. A few countries benefit but most suffer catastrophic damage to their economics with knock on impacts on healthcare and research capability.

Can things get any worse?"


Swine FluEdit

Scenario swine flu
"Patient Zero is infected with a new mutated strain of the Influenza A (H1N1) virus. A reassortment of the 2009 strain with limited lethality - existing anti-virals are moderately effective against it. However, analysis of its genetic make-up has identified potential sequence similarities to the 1918 'Spanish Flu' strain that killed 5% of the world's population.

Will history repeat itself?

About the H1N1 Flu Virus (Wikipedia link)"



"Highly advanced technology has created the opportunity to travel through a portal and teleport to other countries. Meanwhile, after playing realistic plague simulator video games, humans have worked out which countries are likely to be the safest in the event of a global pandemic.

Will they put this knowledge to good use?"


Volcanic AshEdit

Scenario volcanic ash
"Massive volumes of volcanic ash are ejected into the atmosphere from major volcanic eruptions. The majority of flights worldwide are grounded, changing the way that people travel.

Does this cloud have a silver lining?"


Where Is Everyone?Edit

Scenario where is everyone
"Almost everybody in the world has mysteriously vanished and nobody knows why. The Rapture? Mass abductions? Spontaneous combustion? Who knows?! Luckily though, the few thousand people left behind are carrying on as normal. How will your outbreak spread when there are so few people left to infect?" 15

Who CaresEdit

Scenario who cares
"Increased popularity of reality TV in rich countries distracts people and stops them caring about disease outbreaks in poorer countries. Reduced funding significantly impacts the surveillance capacity of poor countries and limits their ability to identify and respond to national disease outbreaks.

Who cares what happens to poor people?"



Scenario xenophobia
"Anger over immigration, globalisation and exploitations trigger a rapid increase in hostility towards foreigners worldwide. Countries heavily fortify their borders - significantly reducing the amount of cross border traffic worldwide.   

On a positive note, border guards get to shout "You shall not pass"..."



In-App PurchasesEdit

Next scenario: $0.99 USD (unlocks the next scenario)
All Scenarios: $2.99 USD (unlocks all scenarios. Future scenarios are free if this is purchased)
Plague Pack: $10.99 USD/$4.99 USD if all normal and special plagues are unlocked (unlocks all scenarios and plagues; normal and special)


  • (Incidentally, the title refers of the Shut Down Everything scenario to the internet meme "Shut Down Everything" inspired by the browser game Pandemic, the inspiration for Plague, Inc.)
  • (Note that the word "Contagion" in the Nipah Virus description starts with a capital letter. So it could be reference to "Contagion", a 20


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