Plague Inc. Wiki
Plague Inc. Wiki
General Information

The Prion is the fifth plague available from Plague Inc. This plague possesses abilities that allow it to resist the Cure better.


The unique trait that Prion has in Plague Inc. is Neural Atrophy, which is like Genetic Hardening, slowing down cure research. Lethality from evolved traits will take longer to take effect, thus Prion will kill slower than other pathogens.


  • Devolving Neural Atrophy will cause the cure effort to speed up, if there is any.
  • Real life prions do not contain any DNA or RNA and can thus not evolve in the way typical pathogens like bacterias and viruses do. They are, effectively, only malfunctioning proteins.
    • Additionally, in real life, Prions cannot be cured, but to keep in balance with the game it is also vulnerable to the cure like the other diseases.

Stages of Evolution

Standard Plague Types


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