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Mr. Universe is a symptom combo exclusive to the Shadow Plague DLC which results in Arnold-like bodies, which increases infectivity. The player can get this if they evolve Anabolic Boost and Pheromone secretion.

Symptom Combos in Plague Inc. and Plague Inc: Evolved.
AssassinBath TimeBlind GeniusBlood in the AirBoomerCarpe JugulumCranial DispersionDiscovery ChannelFly MagnetOn The Naughty ListOopsProfuse BleedingProjectile VomitingPublic DefecationRed Ape RedemptionRed RainRude AwakeningRunnerSpitterSwine FluTankUltimate ChristmasVampire BatWalking ContradictionWalking DeadZombie Panic
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