Except in some scenarios, players can insert one of the genes from Genetic Code before they start their game.  These genes allow personalization of plague, for example, by providing boosts to infectivity and DNA gain, increase/decrease the mutation rate, and so on.

Every time a player wins a game with a standard plague, they unlock one of the 25 genes regardless of the difficulty level. The same goes for Neurax Worm. However, the other special plagues can unlock one of their special genes.

There are five different types of genes: DNA Genes, Travel Genes, Evolution Genes, Mutation Genes, and Environment Genes. Players can only have one of each type of gene per game, meaning that there are a large number of different genetic combinations that one can use for any disease (3,125 to be exact). There are exclusive genes for Necroa Virus, Simian Flu, and Shadow Plague.

On Android, you must buy the premium version for $0.99 in order to use the genes that you unlocked.

Standard Plague Genes

DNA Genes

ATPBoostIcon.png
Gen Name ATP Boost
Description

Get bonus DNA at the beginning (8 extra starting DNA points)

MetabolicJumpIcon.png
Gen Name Metabolic Jump
Description

Get more DNA from popping red, biohazard bubbles

CytochromeSurgeIcon.png
Gen Name Cytochrome Surge
Description

Get more DNA from popping orange DNA bubbles

CatalyticSwitchIcon.png
Gen Name Catalytic Switch
Description

Get bonus DNA from popping blue, cure bubbles

MetabolicHijackIcon.png
Gen Name Metabolic Hijack
Description

Orange and Red bubbles are automatically popped for you

Mutation Genes

DarwinistIcon.png
Gen Name Darwinist
Description

Increases the chance of your plague mutating (+0.4 mutation)

CreationistIcon.png
Gen Name Creationist
Description

Decreases the chance of your plague mutating (-0.4 mutation)

GeneticMimicIcon.png
Gen Name Genetic Mimic
Description

Your Plague is harder to cure (+0.15 cure requirement)

BaseOxidisationIcon.png
Gen Name Base Oxidisation
Description

Your plague can mutate Transmissions. Easier to cure (-0.1 mutation, -0.05 cure requirement)

BaseHydrolysisIcon.png
Gen Name Base Hydrolysis
Description

Your plague can mutate Abilities. Easier to cure (-0.1 mutation, -0.05 cure requirement)

Travel Genes

TeracyteIcon.png
Gen Name Teracyte
Description

Increases chance of your plague spreading by land (+7 infectivity)

AerocyteIcon.png
Gen Name Aerocyte
Description

Increases chance of your plague spreading by air (+7 infectivity)

AquacyteIcon.png
Gen Name Aquacyte
Description

Increases chance of your plague spreading by sea (+7 infectivity)

SuppressionIcon.png
Gen Name Suppression
Description

Plague more likely to cross a closed land border

NativeBiomeIcon.png
Gen Name Native Biome
Description

Increases infectivity in your starting country

Environment Genes

XerophileIcon.png
Gen Name Xerophile
Description

Give your plague a bonus in arid climates (+0.5 infectivity)

HidrophileIcon.png
Gen Name Hydrophile
Description

Give your plague a bonus in humid climates (+0.5 infectivity)

RurophileIcon.png
Gen Name Rurophile
Description

Give your plague a bonus in rural environments (+0.5 infectivity)

UrbophileIcon.png
Gen Name Urbophile
Description

Give your plague a bonus in urban environments (+0.5 infectivity)

ExtremophileIcon.png
Gen Name Extremophile
Description

Give your plague a minor bonus in all environments (+0.2 infectivity)

Evolution Genes

IonisedHelixIcon.png
Gen Name Ionised Helix
Description

Bonus DNA when devolving (+2 DNA points for devolution)

TranslesionIcon.png
Gen Name Translesion +
Description

Costs to devolve don't increase

SymptoStasisIcon.png
Gen Name Sympto-Stasis
Description

Symptom costs don't increase but easier to cure(-0.1 infectivity in all environments, -0.1 cure requirement)

TransStasisIcon.png
Gen Name Trans-Stasis
Description

Transmission costs don't increase but easier to cure (-0.1 infectivity in all environments, -0.125 cure requirement)

PathoStasisIcon.png
Gen Name Patho-Stasis
Description

Ability costs don't increase but easier to cure (-0.1 infectivity in all environments, -0.11 cure requirement)

Note: In the Mega-Brutal difficulty mode, even with the "stasis" genes, the cost to evolve still increases as more people are infected, but with a lesser extent than without the "stasis" genes.

Special Plague Genes

Necroa Virus Genes

Exclusive to Necroa Virus, replacing Evolution Genes

CytopathicBoostIcon.png
Gen Name Cytopathic Boost
Description

Infected corpses are more likely to reanimate as a zombie

AutolyticReductionIcon.png
Gen Name Autolytic Reduction
Description

Slightly decreases the speed at which zombies decay

ThermoNecroIcon.png
Gen Name ThermoNecro
Description

Reduces the zombie rate of decay in hot countries

DopamineInhibitorIcon.png
Gen Name Dopamine Inhibitor
Description

Increases the chance of a zombie victim becoming a zombie

SplicedActivationIcon.png
Gen Name Spliced Activation
Description

Active Abilities cost less DNA to use (from 5 to 3)

Artificial Genes

Exclusive to Simian Flu, replacing Evolution Genes in Plague Inc. and Mutation Genes in Plague Inc: Evolved

LatentCatalystIcon.png
Gen Name Latent Catalyst
Description

Get DNA when a Gen-Sys lab is destroyed

CortisolSensitivityIcon.png
Gen Name Cortisol Sensitivity
Description

Reduces research from Gen-Sys experiments on apes

ATPOverdoseIcon.png
Gen Name ATP Overdose
Description

Bonus DNA at start but costs significantly more to devolve (+15 starting DNA points, +20 devolution cost)

IonDeficitIcon.png
Gen Name Ion Deficit
Description

Costs more to devolve but harder to cure

IonSurgeIcon.png
Gen Name Ion Surge
Description

Costs less to devolve but easier to cure

Ape Genes

Exclusive to Simian Flu, replacing Mutation Genes in Plague Inc. and Evolution Genes in Plague Inc: Evolved

AdrenalSurgeIcon.png
Gen Name Adrenal Surge
Description

Increases ape strength and speed but lethal over time

LeadershipIcon.png
Gen Name Leadership
Description

Active Abilities cost less DNA to use (1/2 cost)

ViralAffinityIcon.png
Gen Name Viral Affinity
Description

Increases ape to ape transmission

TogetherStrongIcon.png
Gen Name Together Strong
Description

Increases DNA from colonies (+1 DNA)

CallOfTheWildIcon.png
Gen Name Call of the Wild
Description

Apes less likely to be found by humans

Blood Genes

Exclusive to Shadow Plague, replacing Mutation Genes in Plague Inc. and DNA Genes in Plague Inc: Evolved

HealthyEaterIcon.png
Gen Name Healthy Eater
Description

Increases vampire maximum health

ScavengerIcon.png
Gen Name Scavenger
Description

Vampire gets more DNA from destroying labs and Templar Bases

BrawlerIcon.png
Gen Name Brawler
Description

Vampire Blood Rage ability doesn't cost DNA

BerserkerIcon.png
Gen Name Berserker
Description

Vampire Blood Rage ability kills more people

HarvesterIcon.png
Gen Name Harvester
Description

Vampire gets more DNA when consuming people using Blood Rage

Flight Genes

Exclusive to Shadow Plague, replacing Evolution Genes in Plague Inc. and Mutation Genes in Plague Inc: Evolved

BatBoltIcon.png
Gen Name Bat Bolt
Description

Vampire Flight range increases

BudgetBatIcon.png
Gen Name Budget Bat
Description

Vampire Flight ability doesn't cost DNA

FairWeatherBatIcon.png
Gen Name Fair Weather Bat
Description

Vampire flies faster when not injured

AerophobicBatIcon.png
Gen Name Aerophobic Bat
Description

Vampire flies faster but damages health

SociallyAwkwardBatIcon.png
Gen Name Socially Awkward Bat
Description

Vampire starts Blood Rage automatically when entering a new country

Shadow Genes

Exclusive to Shadow Plague, replacing DNA Genes in Plague Inc. and Evolution Genes in Plague Inc: Evolved

Witchdoctor.png
Gen Name Witch Doctor
Description

Get bonus DNA at the beginning (8 extra starting DNA points)

Unholyengineer.png
Gen Name Unholy Engineer
Description

Harder for drones to target lairs

Shadowspawn.png
Gen Name Shadow Spawn
Description

Vampire less likely to be spotted in countries with lairs

Frugalresearcher.png
Gen Name Frugal Researcher
Description

Lair DNA bonus triggers with fewer infected people

Madscientist.png
Gen Name Mad Scientist
Description

All bubbles are automatically popped for you

Unlocking via gameplay

You can unlock genes by playing the game in the Casual difficulty.

  • Beating any plague type unlocks a random gene.
    • Beating a Necroa Virus game unlocks a random Necroa gene.
    • Beating a Simian Flu game unlocks a random Simian / Artificial gene.
    • Beating a Shadow Plague game unlocks random a Shadow / Flight / Blood Rage gene.

Multiplayer Genes

Here is a list of some genes in multiplayer games. Some of the genes in multiplayer mode are exclusive to VS Mode.

  • Hydrophobe: Gives your plague a bonus in arid climates, but a penalty in humid climates (+1.33 arid, -1 humid)
  • Xerophobe: Gives your plague a bonus in humid climates, but a penalty in arid climates (-1.33 arid, +1 humid)
  • Urbophobe: Gives your plague a bonus in rural environments, but a penalty in urban environments (-0.67 urban, +0.57 rural)
  • Rurophobe: Gives your plague a bonus in urban environments, but a penalty in rural environments (+0.67 urban, -0.57 rural)
  • Pharmaphile: Gives your plague a bonus in wealthy countries, but a penalty in poor countries (+0.12 rich, -0.5 poor)
  • Pharmaphobe: Gives your plague a bonus in poor countries, but a penalty in wealthy countries (-0.12 rich, +0.5 poor)
  • Frigophobe: Gives your plague a bonus in hot countries, but a penalty in cold countries (+0.1 hot, -0.16 cold)
  • Thermophobe: Gives your plague a bonus in cold countries, but a penalty in hot countries (-0.1 hot, +0.16 cold)
  • Benign infection: Your plague is harder to cure, but you start with less DNA
  • Unstable inception: Get bonus DNA at the beginning, but your starting country will be selected randomly (+9 DNA at the start)
  • Safe house (VS mode exclusive): Get more DNA (from 2 to 4) from bubbles in your starting country, but your opponent gets bonus DNA (+6) when it is discovered
  • Search and Destroy (VS mode exclusive): Get a DNA bonus from finding your opponent's starting country. The bonus decreases the longer it takes
    • If you find your opponent's starting country in 0 days, the bonus will be 40 DNA points. The bonus will be decreasing by 0.13 per day.
  • Base Hydration: Your plague can mutate transmissions and abilities, but costs to evolve will increase quickly
  • Peekaboo (VS mode exclusive): See which countries your opponent has infected when you find their starting country, but get less DNA (-6) when you find it
  • Innocent Infection: Your Plague will find it easier (+50%) to infect people that are already infected by other diseases, but harder (-50%) to kill them
  • Deadly Disinfectant: Your Plague will find it easier (+50%) to kill people that are infected by other diseases, but harder (-50%) to infect them

Trivia

  • Some of the genes have good and bad sides. For some genes that make your plague easier to cure, however, some abilities and symptoms can override that effect.
  • Neurax Worm is the only special plague that doesn't have its own special genes.
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