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Before a player starts their game, they can insert Genetic Code. These genes allow personalization of pathogens by providing boosts to how one infects people, reacts to different environments, acquires DNA, and just the playstyle in general of your pathogen.

Every time a player wins a game with a standard plague, they unlock one of the 25 genes, regardless of the difficulty level. The same goes for victories in the Neurax Worm. However, the other special plagues normally unlock one of their special genes. There are five different types of genes: DNA Genes, Travel Genes, Evolution Genes, Mutation Genes, and Environment Genes. Players can only have one of each type of gene per game, meaning that there are a large number of different genetic combinations that one can use for any disease (3,125 to be exact) . There are exclusive genes for Necroa Virus, Simian Flu, and Shadow Plague. On Android, you must buy the premium version for $1.00 in order to use the genes that you unlocked.

Standard Plague Genes

DNA Genes

ATPBoostIcon
Gen Name ATP Boost
Description

Get bonus DNA at the beginning (8 extra starting DNA Points)

MetabolicJumpIcon
Gen Name Metabolic Jump
Description

Get more DNA from popping red, biohazard bubbles.

CytochromeSurgeIcon
Gen Name Cytochrome Surge
Description

Get more DNA from popping orange DNA bubbles.

CatalyticSwitchIcon
Gen Name Catalytic Switch
Description

Get bonus DNA from popping blue Cure bubbles.

MetabolicHijackIcon
Gen Name Metabolic Hijack
Description

Orange and red bubbles are automatically popped.

Mutation Genes

DarwinistIcon
Gen Name Darwinist
Description

This gene increases the chance of your plague mutating (+0.4 mutation).

CreationistIcon
Gen Name Creationist
Description

This gene decreases the chance of your plague mutating (-0.4 mutation).

GeneticMimicIcon
Gen Name Genetic Mimic
Description

Your plague is harder to cure (+0.15 Cure Requirement).

BaseHydrolysisIcon
Gen Name Base Hydrolysis
Description

Your plague can mutate Abilities, but is easier to cure (-0.1 Mutation, -0.05 Cure Requirement).

BaseOxidisationIcon
Gen Name Base Oxidisation
Description

Your plague can mutate transmissions, but is easier to cure (-0.1 Mutation, -0.05 Cure Requirement).

Travel Genes

TeracyteIcon
Gen Name Teracyte
Description

This gene increases the chance of your plague spreading by land (+7 land).

AquacyteIcon
Gen Name Aquacyte
Description

This gene increases chance of your plague spreading by sea (+7 sea).

AerocyteIcon
Gen Name Aerocyte
Description

This gene increases chance of your plague spreading by air (+7 air).

SuppressionIcon
Gen Name Suppression
Description

Your plague is more likely to cross a closed land border.

NativeBiomeIcon
Gen Name Native Biome
Description

This gene increases infectivity of your plague in its starting country.

Environment Genes

XerophileIcon
Gen Name Xerophile
Description

This gene gives your plague a bonus in arid climates (+0.5).

HidrophileIcon
Gen Name Hydrophile
Description

This gene gives your plague a bonus to infectivity in humid climates (+0.5).

RurophileIcon
Gen Name Rurophile
Description

This gene gives your plague a bonus to infectivity in rural environments (+0.5).

UrbophileIcon
Gen Name Urbophile
Description

This gene gives your plague a bonus in urban environments (+0.5).

ExtremophileIcon
Gen Name Extremophile
Description

This gene gives your plague a minor bonus in all environments (+0.2 in all environments).

Evolution Genes

Note: Mega-Brutal infected population cost increase still applies to the "stasis" genes. Cost will still increase, just at a lesser extent than without the "stasis" genes.

IonisedHelixIcon
Gen Name Ionised Helix
Description

This gene grants bonus DNA when devolving (+2 DNA Points for devolution).

TranslesionIcon
Gen Name Translesion +
Description

Costs to devolve don't increase.

SymptoStasisIcon
Gen Name Sympto-Stasis
Description

Symptom costs don't increase, but your plague will be easier to cure(-0.1 infectivity in all environments, -0.1 cure requirement).

TransStasisIcon
Gen Name Trans-Stasis
Description

Transmission costs don't increase, but your plague will be easier to cure (-0.1 infectivity in all environments, -0.125 cure requirement).

PathoStasisIcon
Gen Name Patho-Stasis
Description

Ability costs don't increase, but your plague will be easier to cure (-0.1 infectivity in all environments, -0.11 cure requirement).

Special Plague Genes

Necroa Genes

(Exclusive to Necroa Virus, replacing Evolution)

AutolyticReductionIcon
Gen Name Autolytic Reduction
Description

This gene slightly decreases the speed at which zombies decay, allowing them to be dangerous for longer periods of time.

CytopathicBoostIcon
Gen Name Cytopathic Boost
Description

Infected corpses are more likely to reanimate as a zombie.

ThermoNecroIcon
Gen Name ThermoNecro
Description

This gene reduces the zombie rate of decay in countries with a Hot climate.

SplicedActivationIcon
Gen Name Spliced Activation
Description

Active abilities cost less DNA (from 5 to 3) to use.

DopamineInhibitorIcon
Gen Name Dopamine Inhibitor
Description

This gene increases the chance of a zombie victim becoming a zombie.

Ape Genes

(Exclusive to Simian Flu, replacing Mutation)

ViralAffinityIcon
Gen Name Viral Affinity
Description

This gene increases the rate of ape-to-ape transmission.

CallOfTheWildIcon
Gen Name Call of the Wild
Description

Apes are less likely to be found by humans.

TogetherStrongIcon
Gen Name Together Strong
Description

This gene increases DNA gained from colonies (+1 DNA).

LeadershipIcon
Gen Name Leadership
Description

Active abilities cost less DNA to use (1/2 cost).

AdrenalSurgeIcon
Gen Name Adrenal Surge
Description

This gene increases ape strength and speed, but it is lethal over time.

Artificial Genes

(Exclusive to Simian Flu, replacing Evolution)

LatentCatalystIcon
Gen Name Latent Catalyst
Description

This gene allows you get DNA when a Gen-Sys lab is destroyed.

CortisolSensitivityIcon
Gen Name Cortisol Sensitivity
Description

This gene reduces research from Gen-Sys experiments on apes.

ATPOverdoseIcon
Gen Name ATP Overdose
Description

Bonus DNA is given at the start, but it costs significantly more to devolve (+15 starting DNA Points), (20 more points devolution cost).

IonDeficitIcon
Gen Name Ion Deficit
Description

It costs more to devolve, but it also makes the Simian Flu harder to cure.

IonSurgeIcon
Gen Name Ion Surge
Description

It costs less to devolve, but the Simian Flu is easier to cure.

Blood Genes

(Exclusive to Shadow Plague, replacing Travel genes)

HealthyEaterIcon
Gen Name Healthy Eater
Description

Increases vampire maximum health.

ScavengerIcon
Gen Name Scavenger
Description

Vampire gets more DNA from destroying labs and Templar Bases.

BrawlerIcon
Gen Name Brawler
Description

Vampire Blood Rage ability doesn't cost DNA

BerserkerIcon
Gen Name Berserker
Description

Vampire Blood Rage ability kills more people.

HarvesterIcon
Gen Name Harvester
Description

Vampire gets more DNA when consuming people using Blood Rage.

Flight Genes

(Exclusive to Shadow Plague, replacing Environment genes)

BatBoltIcon
Gen Name Bat Bolt
Description

Vampire Flight range increases.

BudgetBatIcon
Gen Name Budget Bat
Description

Vampire Flight ability doesn't cost DNA

FairWeatherBatIcon
Gen Name Fair Weather Bat
Description

Vampire flies faster when not injured .

AerophobicBatIcon
Gen Name Aerophobic Bat
Description

Vampire flies faster but damages health.

SociallyAwkwardBatIcon
Gen Name Socially Awkward Bat
Description

Vampire starts Blood Rage automatically when entering a new country

Shadow Genes

(Exclusive to Shadow Plague, replacing DNA Genes)

Witch Doctor

Vampire heals faster when in its lair

Shadow Spawn

Vampire less likely to be spotted in countries with lairs

Mad Scientist

All bubbles are automatically popped for you

Unholy Engineer

Harder for drones to target lairs

Frugal Researcher

Lair DNA bonus triggers with fewer infected people

Unlocking via Gameplay

You can unlock genes by playing the game. Below are some ways people found which gene gets unlocked by which action, mostly tested on mobile (Android/iOS):

Multiplayer genes

Here is a list of some genes on Multiplayer games. Some of the genes on Multiplayer are VS Mode exclusive. This list is less outdated than it was, but is still none-the-less incomplete.

  • Hydrophobe: Gives your plague a bonus in arid climates, but a penalty in humid climates.

(+1.33 arid, -1 humid)

  • Xerophobe: Gives your plague a bonus in humid climates, but a penalty in arid climates.

(-1.33 arid, +1 humid)

  • Urbophobe: Gives your plague a bonus in rural environments, but a penalty in urban environments.

(-0.67 urban, +0.57 rural)

  • Rurophobe: Gives your plague a bonus in urban environments, but a penalty in rural environments.

(+0.67 urban, -0.57 rural)

  • Pharmaphile: Gives your plague a bonus in wealthy countries, but a penalty in poor countries.

(+0.12 rich, -0.5 poor)

  • Pharmaphobe: Gives your plague a bonus in poor countries, but a penalty in wealthy countries.

(-0.12 rich, +0.5 poor)

  • Frigophobe: Gives your plague a bonus in hot countries, but a penalty in cold countries.

(+0.1 hot, -0.16 cold)

  • Thermophobe: Gives your plague a bonus in cold countries, but a penalty in hot countries.

(-0.1 hot, +0.16 cold)

  • Benign infection: Your plague is harder to cure but you start with less DNA.
  • Unstable inception: Get bonus DNA (+9) at the beginning, but your starting country will be selected randomly.
  • Base Hydration: Your plague can mutate transmissions and abilities, but costs to evolve will increase quickly.
  • Innocent Infection: Your plague will find it easier (+50%) to infect people that are already infected by other diseases, but harder (-50%) to kill them.
  • Deadly Disinfectant: Your plague will find it easier (+50%) to kill people that are infected by other diseases, but harder (-50%) to infect them.
  • VS mode Exclusive Safe house: Get more DNA (from 2 to 4) from bubbles in your starting country, but your opponent gets bonus DNA (+6) when it is discovered.
  • VS mode Exclusive Search and Destroy: Get a DNA bonus from finding your opponent's starting country. The bonus decreases the longer it takes. If you find your opponent's starting country in 0 days, the bonus will be 40 DNA points. The bonus will be decreasing by 0.13 per day.
  • VS mode Exclusive Peekaboo: See which countries your enemy has infected but gain less DNA (-6) when discovering thier starting country.

Trivia

  • The Mutation Genes,(Base Oxidisation & Base Hydroylsis) Evolution Genes, (Sympto-Statis, Patho-Statis, & Trans-Statis) And Multiplayer genes have good and bad sides.
  • Neurax Worm is the only special plague that dosen't have its own special genes.
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