The Frozen Virus scenario was introduced in Mutation 1.8 as a Scenario. It was later introduced to the PC as a beta build for Evolution 7 on May 20, 2014, along with the rest of the missing Mega Mutation 8 scenarios. It possesses the ability to invoke forced evolution in its hosts, causing them to "regress" to a more primitive state.
Its default name is Pithovirus in-game, after its eponymous real-life counterpart. On June 30, 2022, the Cure Mode Freeze Virus beta for mobile devices was launched.
- Amoeba 1 - Amoeba susceptible to viral infection and spreads primarily through freshwater and saltwater. Increases infectivity (You automatically start with it).
- Amoeba 2 - Virus manipulates amoebal DNA, allowing host amoeba to thrive in warm body parts of animals. Increases infectivity. (Unlocks all other types of transmissions)
- Amoeba 3 - DNA reshuffled to allow host amoeba to survive and spread in animal faces, increasing infectivity in poor, rural countries.
- Bird 1 - Birds become susceptible to infection. Avian carriers increase infectivity, land transmission and mutation.
- Bird 2 - Avian brain tissue compromised causing birds to attack other species. Increases mutation, infectivity, and land based transmission.
- Rodent 1 - Common flea susceptible to infection. Increase infectivity, especially in urban regions and mutation.
- Rodent 2 - Rodents directly susceptible to infection. Increase infectivity, especially in urban regions and mutation.
- Livestock 1 - Livestock susceptible to infection. Increase infectivity, especially in rural regions and mutation.
- Livestock 2 - Wildlife susceptible to infection. Increase infectivity, especially in rural regions and mutation.
- Insect 1 - Insects susceptible to infection. Carrier insects increase infectivity, especially in hot climates and chance of mutation.
- Insect 2 - Increases rate of transfer between insects. Increase infectivity, especially in hot climates and mutation.
- Water 1 - Pathogen can survive outside the body in fresh, warm water. Increase infectivity, especially in humid environments and ship transmission.
- Water 2 - Pathogen able to survive in chemically treated water. Increase infectivity, especially in humid environments and ship transmission.
- Mandibular Strain - Moderate pain in mastication muscles, especially when eating, and periodical jaw clicking (can't be devolved, you automatically start with it).
- Drooling - Occasional intemperate drooling when sleeping or eating. Increases infectivity slightly (can't be devolved, you automatically start with it).
- Anaemia - Deficiency in the levels of heme contained in the hemoglobin which can lead to hypoxia in the organs.
- Cysts - Painful lumps containing pockets of the pathogen. Slight chance of bursting which can spread disease.
- Edentulism - Severe gum infection causes teeth to fall out.
- Memory Loss - Recent memories become nebulous in patients, replaced with vague historical recollections. Slows cure progress.
- Jaundice - Accelerated viral reproduction in the liver results in bilirubin build-up, causing yellowing of skin, eyes and mucus membrane. Increases infectivity.
- Skin Lesions - Breakdown in the epidermis causes large open wounds which significantly increase infectivity.
- Carnivorous Denticulation - Hormone changes trigger growth of carnivorous teeth and consumption of raw meat. Poor dental hygiene increases infectivity.
- Immaturity - Reduction in hormone levels causes immature and antisocial behavior, reducing cure research. Lower levels of hygiene cause infection.
- Malignant Ascites - Accumulation of fluid in abdominal cavity due to severe cirrhosis. Can be lethal.
- Abscesses - Pockets of infected flesh are painful and act as breeding grounds for the pathogen, increasing infection rates when burst.
- Bone Dysplasia - Relentless bone growth with high mineral density results in severe musculoskeletal stress; lethal in many cases. Broken skin increases infection. (can't be devolved)
- Aphasia - Progressive loss of brain cells damages parts of brain responsible for language and understanding. Makes cure development harder. (can't be devolved)
- Hepatic Failure - Chronic replacement of normal liver cells with scar tissue causes liver to fail, resulting in rapid death.
- Systemic Infection - Pathogen affects multiple organs and tissue types, causing body-wide infections that spread fast and can be fatal.
- Tumours - Pathogen disrupts cell growth pathways, causing uncontrolled, eventually fatal tumour growth.
- Cranial Elephantitis - Increased bone growth places pressure on the brain. Trauma makes cure development significantly harder and can be lethal.
- Aggression - Confusion and immaturity results in lethal primal aggression towards others. Cure progress significantly slowed.
- Hemorrhagic Shock - Failure of the heart to pump effectively causes oxygen deprivation, loss of consciousness and death.
- Neanderthal Regression - DNA recombination destroys logical and emotional brain function, leading to complete regression to Neanderthal state (can't be devolved).
30.000 years of dormancy in Russian permafrost has critically corrupted the virus in spite of its extreme resistance to cold climates.
These traits unlock additional traits when evolved. They can only be evolved in order and can't be devolved.
|DNA Repair 1||Initial repair of low-level protein strands damaged during dormancy. Restore ancient symptoms and ability to stabilize in warmer environments.|
|DNA Repair 2||Partial repair of low-level protein strands damaged during dormancy. Restore ancient symptoms and ability to resist basic immune responses.|
|DNA Repair 3||Full repair of low-level protein strands damaged during dormancy. Restore ancient symptoms and ability to withstand higher temperatures.|
|DNA Repair 4||Initial repair of high-level protein strands damaged during dormancy. Restore ancient symptoms and ability to resist advanced immune response.|
|DNA Repair 5||Partial repair of high-level protein strands damaged during dormancy. Restore ancient symptoms and ability to survive in hot environments.|
|Full DNA Repair||Viral DNA fully reconstructed, giving access to entire genetic code from Neanderthal era. Can now entirely reshape human temperament.|
Cure/Drug Resistance Abilities
These abilities are identical to those featured in standard plagues.
|Drug Resistance 1||Pathogen becomes resistant to class 1 and 2 antibiotics. Increase effectiveness in wealthy countries.|
|Drug Resistance 2||Pathogen develops resistance to class 3 and 4 antibiotics. Increase effectiveness in wealthy countries.|
|Genetic Hardening 1||Pathogen becomes harder to analyse in the lab. Decreases future research speed.|
|Genetic Hardening 2||The pathogen does not reproduce in lab conditions. Decreases future research speed.|
|Genetic ReShuffle 1||Pathogen DNA strands reassembled. More work needed to develop a cure.|
|Genetic ReShuffle 2||A new strain of the pathogen now exists, increasing the work needed to develop a cure.|
|Genetic ReShuffle 3||Multiple strains of the pathogen now exist, increasing the work needed to develop a cure.|
These abilities affect the plague's ability to spread in different environments.
|Cold Resistance 1||Pathogen is naturally used to withstanding cold temperatures and climates. (Can't be devolved, you start with it)|
|Cold Resistance 2||Hardened virus capsid ensures pathogen survival in extremely cold environments. (Can't be devolved, you start with it)|
|Cold Resistance 3||30,000 years of surviving beneath layers of ice have completely solidified virus's lipid covering, ensuring survival at sub-zero temperatures. (Can't be devolved, you start with it)|
|Heat Resistance 1||Pathogen evolves to withstand hot temperatures and climates.|
|Heat Resistance 2||Pathogen evolves some resistance to high temperatures. Increased effectiveness in hot climates.|
|Heat Resistance 3||Pathogen avoids cellular breakdown in high temperatures. Increased effectiveness in hot climates.|
|Ice Resistance||Pathogen able to survive and spread in crystalline sea water when ice melts. Increases infectivity by sea, and is harder to detect.|
- If the player wants all symptoms available, they should focus on the DNA repair trait first.
- Neanderthal Regression can be used to cripple cure efforts.
- Since the virus begins in Russia, players should plan out their strategy to reflect the sea traffic of Russia.
- The virus is already by nature highly resistant to cold climates, saving you significant amounts of DNA for other traits such as the Heat Resistance abilities it lacks.