Plague Inc. Wiki
Main Article: Genetic Code

Extremophile is a gene available for the standard plagues , in addition to the Neurax Worm, Necroa Virus, Simian Flu and Shadow Plague DLCs. When this gene is applied, it gives the pathogen a small bonus of effectiveness in all environments.

The all environments bonus provided by the gene does not include improvements regarding the adaptation of the plague in cold or hot climates.


  • The Twinfinite website recommends using this gene in order to defeat Bacteria.[1] In addition, the Italian video game news website recommends using this gene in the genetic code of the Nano-Virus.[2]
  • It is recommended to use this gene to be able to spread in countries with certain climates where they do not usually receive as many flights or ships, such as New Guinea and sometimes Madagascar, where environmental factors acts as the main cause of infection.


  1. Banat, Omar (2020-03-10). "Plague Inc: How to Beat Bacteria on Brutal". Twinfinite Retrieved on April 29, 2022.
  2. Longobardi, Michele (2018-09-26). "[Guida] Plague Inc. | Come contagiare il mondo con il nano virus". (in Italian) Retrieved on April 29, 2022.