Plague Inc. features several different types of diseases, each with different advantages and disadvantages. All types of Disease can be unlocked through completing the game, but they can be purchased as In App Purchases to bypass unlocking them manually.
| Unlockable order | Disease Name | Description |
|---|---|---|
| 1 | Bacteria | Most common cause of Plague. Unlimited Potential |
| 2 | Virus | A rapidly mutating pathogen which is extremely hard to control |
| 3 | Fungus | Fungal Spores struggle to travel long distances without special effort |
| 4 | Parasite | Parasitic lifestyle prevents DNA alteration from everyday infection |
| 5 | Prion | Slow, subtle and extremely complex pathogen hidden inside the brain |
| 6 | Nano-Virus | Out of control, microscopic machine with a built in kill switch |
| 7 | Bio-Weapon | Exceptionally lethal pathogen that kills everything it touches |
| 8 | Neurax Worm | Manipulative organism that burrows into the brain |
| 9 | Necroa Virus | Necroa Virus is unclassified. Early analysis suggests extreme regenerative abilities |
| 10 | Simian Flu | Genetically modified. Increases ape intelligence but untested on humans... |
| 11 | Shadow Plague | Sentient, mutagenic pathogen. Triggers a powerful thirst for blood! |