Not to be confused with Cure Mode
Cure icon.png

The Cure is humanity's last defense against a plague. Once a plague becomes spotted, cure development starts shortly after.

The cure, once completed, causes development teams to rush all over the world to begin to rapidly heal the infected. Once all of the infected have been cured, the game ends in a defeat.

Research Facilities

Research Facilities are a feature in the coding of Plague Inc. and Plague Inc: Evolved which mediate how much cure research money a certain country has.

They provide a major challenge for the player in the form of cure development. Each country has its own research facilities, and each facility invests $1,146.56 daily for the cure. There are a total of 340 facilities in the normal Plague Inc. world, with each country (or group of countries) having 2-10 of its own. Listed below are countries by how many facilities they have each in Plague Inc. The amount of money can be increased by government actions such as a martial law declaration.

Countries by number of research facilities (total: 340)

Note: During Sovereign default they have less total research facilities (282) and more in Golden age (446). And in Mirror Earth the numbers are inverted (Rich becomes poor, poor becomes rich, etc).

Country Estimated Number of research facilities Maximum medical research/day (in thousands of dollars)
India 6 6.8
China 10 11.4
West Africa 3 3.4
East Africa 3 3.4
USA 10 11.4
S.E Asia 4 4.5
Indonesia 4 4.5
Brazil 7 8.0
Pakistan 4 4.5
Russia 6 6.8
Japan 10 11.4
Mexico 5 5.7
Central Africa 3 3.4
Germany 10 11.4
Philippines 4 4.5
Colombia 4 4.5
Egypt 4 4.5
France 10 11.4
Iran 4 4.5
Korea 8 9.1
Turkey 5 5.7
Saudi Arabia 8 9.1
UK 10 11.4
Balkan States 5 5.7
Italy 9 10.3
Argentina 6 6.8
Spain 10 11.4
South Africa 8 9.1
Algeria 3 3.4
Central Asia 3 3.4
Sudan 3 3.4
Middle east 6 6.8
Ukraine 4 4.5
C. America 5 5.7
Central Europe 10 11.4
Poland 5 5.7
Caribbean 4 4.5
Canada 10 11.4
Iraq 3 3.4
Morocco 6 6.8
Afghanistan 3 3.4
Peru 4 4.5
Australia 10 11.4
Madagascar 4 4.5
Angola 3 3.4
Kazakhstan 3 3.4
Baltic States 5 5.7
Zimbabwe 3 3.4
Bolivia 2 2.3
Sweden 10 11.4
New Guinea 3 3.4
Libya 3 3.4
Finland 10 11.4
Norway 10 11.4
New Zealand 10 11.4
Botswana 3 3.4
Iceland 9 10.3
Greenland 3 3.4
Total 340 386.5

Country Estimated Number of research facilities
Default Sovereign Default Golden Age Mirror Earth
India 6 6 10 6
China 10 14 14 2
West Africa 3 3 4 9
East Africa 3 3 4 9
USA 10 5 12 2
S.E Asia 4 4 5 8
Indonesia 4 4 8 8
Brazil 7 5 12 5
Pakistan 4 4 5 8
Russia 6 3 9 6
Japan 10 7 12 2
Mexico 5 4 9 7
Central Africa 3 3 4 9
Germany 10 10 12 2
Philippines 4 4 5 8
Colombia 4 4 5 8
Egypt 4 4 5 8
France 10 6 12 2
Iran 4 4 5 8
Korea 8 5 11 4
Turkey 5 5 9 7
Saudi Arabia 8 11 12 4
UK 10 6 12 2
Balkan States 5 5 6 7
Italy 9 5 11 3
Argentina 6 4 8 6
Spain 10 6 12 2
South Africa 8 5 11 4
Algeria 3 3 4 9
Central Asia 3 3 4 9
Sudan 3 3 4 9
Middle east 6 5 8 6
Ukraine 4 4 5 8
C. America 5 5 6 7
Central Europe 10 5 12 2
Poland 5 5 8 7
Caribbean 4 4 5 8
Canada 10 10 12 2
Iraq 3 3 4 9
Morocco 6 6 8 6
Afghanistan 3 3 4 9
Peru 4 4 5 8
Australia 10 10 12 2
Madagascar 4 4 5 8
Angola 3 3 4 9
Kazakhstan 3 3 4 9
Baltic States 5 5 6 7
Zimbabwe 3 3 4 9
Bolivia 2 2 3 10
Sweden 10 6 12 2
New Guinea 3 3 4 9
Libya 3 3 4 9
Finland 10 6 12 2
Norway 10 6 12 2
New Zealand 10 7 12 2
Botswana 3 3 4 9
Iceland 9 8 11 3
Greenland 3 3 4 9
Total 340 287 446 356


  • In the scenario Sovereign Default, there are 282 active research facilities, with China having the most potential investment into a cure, spending at maximum $16,051.84 per day (the same amount as 14 facilities operating under key conditions).
  • In the scenario Golden Age, there are 375 active research facilities, with most countries having a 20% research budget. China has 14 research facilities, spending at maximum $16,051.84 per day.
  • Bolivia has the least amount of research facilities, in most scenarios. Except for the Mirror Earth scenario, in which Bolivia is the country with the most research facilities.

Anti-Cure measures

  • Plagues are more likely to be spotted through severity rises caused by gaining symptoms. To avoid early cure progress, avoid gaining severe symptoms.
    • In Mega-Brutal difficulty, plague discovery can happen randomly even without severity later on in the game, forcing the player on an aggressive approach.
  • The amount of money countries will spend depends on plague severity, lethality and how important a specific infected country is to the rest of the world (may differ depending on scenario and plague type).
  • Delaying the cure is very important (General options are: Evolve Genetic Hardening 1 and 2 to slow future research, and evolve Genetic ReShuffle 1/2/3, or evolve stifling symptoms such as Coma, Seizures, Paralysis and insanity to further delay research. Lethality is also an option
  • In Science Denial, if cure progress reaches 100% for the first time in a game, it will instantly reset to zero due to angry protesters destroying the main research facility. This effectively translates to the cure requiring twice the research in order to develop.
  • Warnings will be issued in popups when cure development has reached 25%, 50%, 75%, 95%, and lastly, 100%.
  • You will be given the tip to use Drug Resistance abilities to delay the cure once it reaches 75%, and the tip to take some extra actions if it reaches 95%.
    • Ironically, Drug Resistance abilities do not affect the cure in any way, although they do unlock ability's that slow down the cure.
  • Even if the cure has been completed, doing anything that sets back progress (such as evolving Genetic Reshuffle/Coma or destroying Gen-Sys / WHO labs) will still bring down the cure progress by adding requirements, preventing anymore people from being cured and allowing them to be reinfected.
  • The more dead people they have, the less money they can spend. Some government actions can restore broken flasks such as Martial Law.
  • Countries can no longer contribute towards future cure progress if their government has been destroyed.
  • How much money they are spending can be found in their information screen as well as their priority (research speed).
  • Abilities such as Genetic Hardening 1 and 2 as well as most traits (especially symptoms like Coma and Seizures) will increase the money needed to complete research. Genetic ReShuffle will actually decrease the total money already spent.
  • Another factor in cure speed is how much the researchers work, which depends on the difficulty setting. It is unknown how exactly this affects the cure progress, but it is obvious that the more they work, the faster the cure will progress.

Variations of Cure with other pathogens


  • Being a microscopic robot, the Nano-Virus is immune to conventional cures and is instead tackled by the Cure Broadcast, which is designed to activate the built-in kill switch that will shut down the bots.
    • What makes the Cure Broadcast truly different is the fact that it starts at the beginning of the game, when the player does not have much DNA to get counter-cure traits. It also advances as fast as a regular cure does. However, Nano-Virus has many more options against the cure broadcast, significantly exceeding that of any other plague. It's best to obtain Kill Switch Stasis as fast as possible.
  • Conventional counter-cure abilities are still available, and should also be taken into account. They stack with Nano-Virus' special effects.

Necroa Virus

  • Necroa Virus lacks many cure delaying symptoms and abilities otherwise present in most pathogens, thus it requires less time for a cure to be researched, and also has a -0.5 modifier for the cure (Equivalent of 2 genetic reshuffles). However, Zombies cannot be cured. The only penalty with the cure being complete is that the Virus can no longer kill without zombies.

Simian Flu

  • In the Simian Flu DLC, the cure is instead developed by Gen-Sys, the company which developed and accidentally released the virus.
    • They may set up labs near ape colonies to gather data and capture apes to use them in deadly experiments, as well as other countries with large ape population.
    • If a Gen-Sys lab is successfully raided and overwhelmed by rampaging apes, cure progress is set back.

Shadow Plague

  • The Shadow Plague cannot undergo cure research until Shadow Blessing is acquired.
    • The Templars will still be able to fight Vampires, in addition to their research capabilities against the plague.
  • If the cure reaches 100%, then there will be a news pop-up saying that the vampire is being poisoned every time it feeds because people are injected with the cure. This could eventually cause the game to end in defeat.
  • Destroying Templar Bases before the cure will remove a considerable amount of progress.
  • Like the Gen-Sys labs, WHO also uses labs to speed up research dramatically. However, they are easily destroyed.

Cure Mode

In cure mode, the namesake subject (also named Vaccine) is allied to the player, and is their goal in achieving a victory. The cure must be properly developed before Authority is drained. When done, it is distributed to the rest of the world


  • The cure is not 100% required in all cases for a victory, as the pandemic can suffer from an extinction scenario where it kills too many people with lethality before it infects more, resulting in the humans winning without a cure. This occurs exclusively with Bio Weapon.
  • Cure development cannot be started until the plague has been properly identified via analysis without the relevant initiatives.
    • The Bacteria and virus do not require an analysis.
  • Cure development undergoes two phases:
    • Research: Begins after Vaccine Research is funded
      • Research can be accelerated/decelerated by various means.
        • Initiatives: Accelerated Research, Accelerated Manufacturing, Global Research Treaty, Global Manufacturing Treaty, Advanced Antibiotics, Convalescent Plasma, Monoclonal Antibody Treatment.
          • Flask bubbles spawned with Field Research can also accelerate its progress.
        • Patient Zero may be identified in the origin country, giving a 10% boost to cure progress.
        • If the experimental cure triggers adverse reactions, it will be set back 10%
  • It can also be accelerated by Improved Supply Chains, Global Manufacturing Treaty and Accelerated Manufacturing


  • Prion takes much more time to analyze due to its neuro-degeneration abilities without "Rapid Analysis".
  • Cure research is also slower without the use of "Neural Enhancers", which damages the efforts of infected countries.
  • Since its lethality is infinite, Extend Incubation 1/2 can help in delaying Prion's progress by increasing the incubation period, thereby preventing it from killing the infected early, while Reassure Infected 1/2 reduces authority loss from those infected with Prion.


  • Nano-Virus is still disabled via its cure broadcast instead of a regular cure. There is no manufacturing phase - once developed, the infected are instantly cured and the player wins.
    • Research begins with "Develop Kill-Code".
      • It can only be accelerated by Kill-Code Supercomputing.
    • When against Nano-Virus, the player has a set of special abilities regarding it to tackle its progress. However, if one of the initiatives in a category gets funded, the other become unusable, as Nano-Virus locks its firewalls.
      • Hack Secondary Routines
        • Emotion Dampening - Increases authority, reduces authority loss from deaths and panicking.
        • Location Tracking - Increases tracing responses' effectiveness.
      • Special Codes
        • Cycle Suspension - Paralyzes Pathogen for 1 month.
        • Cryptomnining - Gain resources over time.
      • Hack Climate Routines
        • Scramble Heat/Cold Resistance - Reduces effectiveness of the pathogen in Hot/Cold climates.

Bio Weapon

  • Bio Weapon is special in that while regular research is possible, the lack of any stalling methods and its skyrocketing infectivity/lethality boost makes it literally unstoppable.


  • If the Immune Strain Cheat was activated with Nano-Virus the cure broadcast will still progress, although as usual it doesn't end.
  • Deaths caused by a plague will only start to be attributed to the plague in pop-ups once it has been confirmed and named. If the plague is not detected at all after everyone dies, it will never even be mentioned by scientists. This is particularly true for a full stealth Shadow Plague in the Where Is Everyone? scenario (as in any other case, there are simply too much people to waste the Vampire's time on).
  • Likewise, it is possible for a cure for any plague to start (and even complete) before any spotting is done due to global awareness when the plague is all over the place, especially on Mega Brutal difficulty and for the Nano-Virus.
  • In the scenario Sovereign Default, there are 282 active research facilities, with China having the most potential investment into a cure, spending at maximum $16,051.84 per day (the same amount as 14 facilities operating under key conditions).
  • In the scenario Golden Age, there are 375 active research facilities, with most countries having a 20% research budget. China has 14 research facilities, spending at maximum $16,051.84 per day.
  • Bolivia has the least amount of research facilities in any given scenario.
  • When the leaving country and destination country are wiped out while the research team is flying to the destination country, research and flying back is still done without anyone alive in either country.
  • All classic symptoms except Total Organ Failure cause at least an additional 1% cure funding requirement (not the same as actual cure speed or progress), making evolving all symptoms a decent last resort to set back cure progress if not already done.


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