Coma is a tier 4 symptom. It is also available in the Simian Flu, Neurax Worm, Black Death，Mad Cow Disease and the Necroa Virus DLCs. It has neuropathic effects in the brain stem, which causes loss of consciousness and death. In the Black Death scenario, it is already evolved at the start of the game.
- Of all the standard symptoms that specifically make the plague harder to cure (Coma, Paralysis, and Insanity), Coma has the largest effect of all of them (+24%).
- This symptom has a low lethality rate compared to other tier 4 symptoms, meaning it is usually used to slow cure progress rather than to kill rapidly.
- In Necroa Virus, Coma, along with Fever weren't lethal. They do have other effect. While Coma in Necroa Virus decrease infectivity, Fever slows research speed.
- If you got Sympto-Stasis then in Nano-Virus mode, this, along with Insomnia, Paranoia and Paralysis won't cost any DNA, which means it's free to upgrade!