Plague Inc. Wiki
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Main Game | Cure Mode

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« Pathogenic bacteria are a major cause of human death and disease. Typically a few micrometres in length; they are extremely adaptable and can spread rapidly. »
— Description of Bacteria in Plague Inc.: The Board Game

The Bacteria is a standard plague. As the first plague type available to choose, it possesses all normal abilities, symptoms and transmissions.


Main Mode

The bacteria don't have many strengths or weaknesses in the Main Mode, this type of disease has extra abilities that help it spread in certain environments. This type of disease has no problem spreading through land, air or water, although it requires the evolution of certain transmissions in order to propagate quickly. The bacteria may sometimes mutate a few symptoms from time to time as it has a default mutation of 0.5, although the player can increase it through transmissions.

Cure Mode

The bacteria can be easily traced as it presents obvious symptoms and does not require testing. This type of disease has no special operations, nor does it have many strengths so it is easy to treat and cure, unlike the other plagues in this mode.

Special Ability

The special ability for Bacteria is Bacterial Resilience, which raises its survivability and effectiveness in all climates. It does not give Drug Resistance and the boost is worse than those provided by Cold/Heat Resistance individually.


Recommended Genes
DNA Gene Metabolic Jump
Mutation Gene Genetic Mimic
Travel Gene Aquacyte
Environment Gene Extremophile
Evolution Gene Sympto-Stasis
Source: Twinfinite[1]

The bacteria is a pathogen that can adapt in almost all environments, so the player can start in any country and wait for the world to become infected, although some are more recommendable such as South Africa and Saudi Arabia, the ports and airports of these two countries are used by many people from different parts of the world, so it helps to spread the disease quickly, alternatively, the player can start in Egypt and use the insect transmissions.[2]

It is possible that the player in the early game has to devolve mutated symptoms, at least symptoms with certain severity or lethality. Having mutated symptoms early in the game may cause people to detect the disease and try to cure it when it has not yet spread effectively throughout the world. In addition, evolving air and water transmissions is important to spread the bacteria, and depending on which country the disease started in, one should use climate resistances, in other words, if the player started in a country with a hot climate, the disease will have an effectiveness bonus for these climates, but would have to evolve cold resistance to be able to adapt to other countries with different climates. When all island nations have a considerable number of infected, it is advisable to evolve Necrosis or Total Organ Failure.[2]


  • It is required to unlock the Insane Bolt achievement.
  • Bacteria, along with Parasite, Prion and Bio-Weapon, are one of the plagues in which there is a refund or don't cost DNA points when devolving traits, therefore it is useful to use the Ionised Helix gene.[3]
  • Bacteria is a type of disease available in Plague Inc.: The Board Game,[4] it was added when the Board Game's Kickstarter was launched.[5]
  • Bacteria is one of the five plagues that appears in Multiplayer Mode, this type of disease along with Virus were available in this mode when it was first released in 2015.
  • Some of the code used in the Bacteria was reused for the Black Death scenario.[6]

Stages of Evolution

Stage 1
Stage 2
Stage 3
Stage 4

Cure Mode Traits

Main Article: Cure Mode

Trait Descriptions

  1. Well Understood: Does not need to be analysed before control actions can be taken
  2. Coughing: Chance of infection by spreading pathogen into surroundings. Increases infectivity
  3. Internal Haemorrhaging: Arterial membranes break down, causing rapid internal bleeding and death
  4. Rash: The skin becomes blistered and painful, slightly increasing infectivity
  5. Hyper Sensitivity: Increases likelihood of allergic reactions which can distract the immune system
  6. Obvious Symptoms: Spread of the disease can be seen before investigation teams have been set up
  7. Necrosis: Large swathes of infected tissue lose blood supply and become fatally gangrenous



  1. "Plague Inc: How to Beat Bacteria on Brutal" (2020-03-10). Twinfinite Retrieved on April 28, 2022.
  2. 2.0 2.1 Madanapalle, Aditya (2021-04-15). "Plague Inc strategies – Ensuring the extinction of humanity". Retrieved on April 25, 2022.
  3. @NdemicCreations (2019-02-25). "That explains it! This gene is useful for plagues that refund or don't cost to devolve, such as Bacteria, Prion, Bio-Weapon, and Parasite. For other plagues where you have to pay to devolve, it reduces the devolving cost". Twitter Retrieved on May 5, 2022.
  4. "Ndemic Creations Plague Inc Board Game Review" (2017-03-28). The Brick Castle Retrieved on April 28, 2022.
  5. "Project successful - 1046% funded!" (2016-05-31). Ndemic Creations Official Website Retrieved on April 28, 2022.
  6. "Stats of the Black Death Scenario" - Game Files
Standard Plague Types