Assassin is a symptom combo exclusive to the Simian Flu DLC which allows apes to use their stealth abilities when attacking. It significantly increases the combat abilities of apes. Primal Awareness and Ape Rampage are required to make this combo. The combo name itself is the reference to the Assassin's Creed game and franchise.
| Symptom Combos | |
|---|---|
| Standard Plagues | Red Rain ▪ Oops ▪ Projectile Vomiting ▪ Public Defecation ▪ Red Rain ▪ Swine Flu Walking Dead |
| Simian Flu | Assassin ▪ Blind Genius ▪ Discovery Channel ▪ Fly Magnet ▪ Red Ape Redemption ▪ Rude Awakening ▪ Zombie Panic |
| Necroa Virus | Bath Time ▪ Blood in the Air ▪ Boomer ▪ Cranial Dispersion ▪ Runner ▪ Spitter ▪ Tank ▪ Walking Contradiction ▪ Vampire Bat |
| Shadow Plague | Carpe Jugulum |
| Cure Mode | Report thy neighbour ▪ Rules are for losers ▪ We're here to help ▪ Happy Frogs ▪ Weapon X ▪ In it together ▪ Humans weren't meant to fly ▪ Shut down everything |
| Santa's Little Helper | On The Naughty List ▪ Ultimate Christmas |