Active abilities cost DNA Points and can be used for many things, such as infecting new countries.
The Neurax Worm ability is called Trojan Planes. Trojan Planes are planes that contain people who are infected with the Neurax worm, who are driven by brain chemicals such as dopamine, testosterone/estrogen, and serotonin. These planes can be flown from an infected country to another country, regardless as to whether or not there is an airport based there, or whether that airport is closed. Trojan Planes will randomly appear on the map. An orange marker will appear for 10 seconds in any infected country. The player can then direct the plane to any other country. Although they do appear randomly, they can appear more frequently if the player evolves Trojan Planes abilities to do so. The tree can also be upgraded to increase the infectivity or lethality of the worm.
This Zombie Horde ability is quite similar to Trojan Planes. With it, a player can gather a horde of zombies and then send them into another country. They can be used to infect healthy countries, and also to eliminate human resistance like Z Com. However, unlike Trojan Planes, Zombie Horde can only attack a country that is neighboring the deployed Horde. However, they can travel at sea, although sea travel will be significantly slower, unless having evolved Drifting Fermentation. Zombie Horde must be dragged to a country, and it must have at least 20 zombies for the ability to work. Certain abilities can be evolved to make hordes faster, or improve the size of them.
The Reanimate ability will reanimate zombies that have already died of natural causes or have been killed. They can be dragged to any country, and require a certain amount of killed or decayed zombies. Certain abilities can be evolved to make the reanimated zombies more powerful, and gain bonuses in combat, as well as some symptoms.
Travel is an active ability exclusive to the Simian Flu DLC. It allows the player to move apes to different countries. It is the equivalent of the Zombie Horde ability in the Necroa Virus DLC. It is used to infect healthy countries, avoid drones, and also to help apes migrate to colonies.
Create Colony is a Tier 2 active ability exclusive to the Simian Flu DLC. It allows the player to form ape colonies, which rescue other apes and protect themselves. The other benefit of having ape colonies is that they will also generate DNA bubbles. Apes can migrate to nearby colonies with the appropriate upgrades from the Ape Migration tree, and colonies may be moved by using the Travel active ability. Creating apes colonies also rises the cost to build other ones. If Gen-Sys sets up a lab in a country with a well-hidden ape colony, the lab will search for apes before starting research. They will continue harvesting apes until they give up and move to another country that has apes.
The Shadow Plague has three Active Abilities: Therianthropy, Blood Rage, and Lair. Like the Simian Flu, they can be used to directly impact the Cure Effort. However, unlike the Simian Flu, the Lair is defensible.
This Therianthropy Ability can be used to transport one Vampire at a time to another country within its flight radius. This radius can be expanded by evolving Travel Speeds 1 to 2. This can be used in conjunction with Blood Rage to assault and destroy Templar Bases.
This Blood Rage Ability can be used to cause the Vampire to attack the population of a country. This can be upgraded by evolving up to Demonic Fury. This can be used in conjunction with Therianthropy to assault and destroy Templar Bases. In addition to this, Blood Rage can be used to destroy drones sent by the Templars to destroy Vampire Lairs.
- There is a question mark which contains the descriptions of the active abilities.